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丁二磺酸腺苷蛋氨酸联合熊去氧胆酸对慢性乙肝合并黄疸患者肝功能及胆红素的影响

Effect of Ademetionine 1,4-butanedisulfonate Combined with Ursodeoxycholic Acid on Liver Functions and Bilirubin in Patients with Chronic Hepatitis B Complicated with Jaundice
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摘要 目的:探讨丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗慢性乙肝合并黄疸的效果,以及对患者肝功能和胆红素的影响.方法:回顾性分析2017年3月—2019年1月我院收治的96例慢性乙肝合并黄疸患者的病例资料,根据治疗方式的不同分为两组,各48例.对照组予以丁二磺酸腺苷蛋氨酸冻干粉针剂(1000 mg加入浓度为5% 的葡萄糖注射液250 mL中静脉滴注,qd)治疗,观察组在对照组基础上加用熊去氧胆酸(500 mg,bid)治疗,比较两组肝功能、胆红素变化及不良反应发生率.结果:与治疗前比较,治疗后两组谷氨酰转肽酶(GGT)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)及总胆汁酸(TBA)水平均下降,且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗前后直接胆红素(D-BIL)水平及治疗期间不良反应发生率比较,差异均无统计学意义(P>0.05);治疗后两组间接胆红素(I-BIL)及总胆红素(T-BIL)较治疗前均升高,且观察组高于对照组,差异有统计学意义(P<0.05).结论:丁二磺酸腺苷蛋氨酸与熊去氧胆酸联合治疗慢性乙肝合并黄疸的效果理想,可有效改善患者的肝功能及胆红素水平,且安全性高,具有较高的推广价值. Objective:To investigate the effect of ademetionine 1,4-butanedisulfonate combined with ursodeoxycholic acid on chronic hepatitis B complicated with jaundice and its effect on liver functions and bilirubin.Methods:The case data of 96 patients with chronic hepatitis B complicated with jaundice admitted to our hospital from March 2017 to January 2019 were retrospectively analyzed,and the patients were divided into two groups according to different treatment methods,48 cases each.The patients in the control group were treated with ademetionine 1,4-butanedisulfonate freeze-dried powder injection(1000 mg drug was added to 250 mL 5%glucose injection,intravenous drip,qd),and the patients in the observation group were treated with ursodeoxycholic acid(500 mg,bid)on the basis of the control group.The liver functions,bilirubin changes and adverse reactions in the two groups were compared between the two groups.Results:Compared with before treatment,the levels of glutamyl transpeptidase(GGT),aspartate aminotransferase(AST),alanine aminotransferase(ALT)and total bile acid(TBA)in the two groups were decreased after treatment,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).There were no statistically significant differences in the level of direct bilirubin(D-BIL)before and after treatment and the incidence of adverse reactions during the treatment(P>0.05).The levels of indirect bilirubin(I-BIL)and total bilirubin(T-BIL)after treatment were higher than those before treatment in the two groups,and the levels in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Ademetionine 1,4-butanedisulfonate combined with ursodeoxycholic acid has an ideal effect in the treatment of chronic hepatitis B complicated with jaundice,which can effectively improve the liver functions and the bilirubin level of the patients,and has high safety and high popularization value.
作者 张改玲 Zhang Gai-ling(Department of Gastroenterology,Henan Honliv Hospital,Xinxiang Henan 453400,China)
出处 《中国合理用药探索》 CAS 2019年第6期50-52,共3页 China Licensed Pharmacist
关键词 慢性乙肝 黄疸 丁二磺酸腺苷蛋氨酸 熊去氧胆酸 肝功能 胆红素 Chronic Hepatitis B Jaundice Ademetionine 1,4-butanedisulfonate Ursodeoxycholic Acid Liver Function Bilirubin
作者简介 张改玲,女,副主任医师。研究方向:消化科。E-mail:zhanggailingzgl@163.com
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