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成人支气管哮喘患者血清25-羟维生素D3水平及其与肺功能的关系 预览 被引量:5

Serum 25(OH)D_3 concentrations and lung function test in adult asthma
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摘要 目的了解成人支气管哮喘(简称哮喘)患者血清25-羟维生素D3[25(OH)D3]水平,为哮喘的治疗提供新的策略。方法收集门诊确诊哮喘患者162例,通过电化学发光法检测患者血清25(OH)D3浓度,以德国JAEGER肺功能仪检测哮喘患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1),计算第1秒用力呼气容积占预计值百分比(FEV1%pred)、FEV1/用力肺活量。根据患者FEV1情况行支气管激发或舒张试验。对25(OH)D3与乙酰甲胆碱PD20FEV1(PD20MCH-FEV1)、FEV1增加值、FEV1增加率的相关性进行分析。结果哮喘患者血清25(OH)D3浓度均低于正常参考值。支气管激发试验中,25(OH)D3与PD20MCH-FEV1呈正相关(P<0.001,r=0.73);支气管舒张试验中,25(OH)D3与FEV1增加值及增加率均呈正相关(r分别为0.53、0.59,P值均0.01)。结论成人哮喘患者血清25(OH)D3浓度比正常值低;血清25(OH)D3浓度与哮喘患者气道高反应性呈负相关,与β2受体激动剂作用后气道阻塞的改善情况呈正相关。 Objective To determine the serum 25hydroxy vitamin D3(25(OH)D3) levels in adult bronchial asthma(asthma) patients and its relationship to lung function.Methods A total of 162adults with asthma were enrolled,serum 25(OH)D3 was determined using the electrochemiluminescence method.Lung function was measured with the Germany JAEGER lung function instrument,which include forced vital capacity(FVC),forced expiratory volume in 1second(FEV1),FEV1%predicted and FEV1/FVC ratio were then calculated.Bronchial provocation test or bronchial relaxation test were performed based on the value of FEV1.The relationship between serum 25(OH)D3 concentrations and PD20FEV1 for methacholine(PD20MCH-FEV1),increase in FEV1,increase in FEV1 ratio were all analyzed.Results The serum 25(OH)D3 concentrations were lower in adult asthma patients compared to the reference values in healthy adults.In patients underwent bronchial provocation test,positive correlation was found between PD20MCH-FEV1 and serum 25(OH)D3(r=0.73,P<0.01).In patients underwent bronchial relaxation test,serum 25(OH)D3 concentrations were positively correlated with both increase in FEV1 and increase in FEV1 ratio(r=0.53 and 0.59,respectively,P<0.01).Conclusions In adult asthma,serum 25(OH)D3 concentration is lower than the reference values in healthy adults,and related negatively with airway hyperresponsiveness(AHR),and positively with the improvement of airway obstruction in patients received with β2 receptor agonist.
作者 任芳萍 刘大鹏 杨军兰 杨娟利 张瑶 吴朔 吴昌归 REN Fang-ping,LIU Da-peng,YANG Jun-lan,YANG Juan-li,ZHANG Yao,WU Shuo,WU Chang-gui.Department of Respiratory Medicine,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,China
出处 《中华哮喘杂志(电子版)》 2013年第4期16-19,共4页 Chinese Journal of Asthma(Electronic Version)
关键词 哮喘 羟维生素D 支气管激发试验 支气管舒张试验 Asthma 25hydroxy vitamin D3 Bronchial provocation test Bronchial relaxation test
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