Objective To determine the serum 25hydroxy vitamin D3(25(OH)D3) levels in adult bronchial asthma(asthma) patients and its relationship to lung function.Methods A total of 162adults with asthma were enrolled,serum 25(OH)D3 was determined using the electrochemiluminescence method.Lung function was measured with the Germany JAEGER lung function instrument,which include forced vital capacity(FVC),forced expiratory volume in 1second(FEV1),FEV1%predicted and FEV1/FVC ratio were then calculated.Bronchial provocation test or bronchial relaxation test were performed based on the value of FEV1.The relationship between serum 25(OH)D3 concentrations and PD20FEV1 for methacholine(PD20MCH-FEV1),increase in FEV1,increase in FEV1 ratio were all analyzed.Results The serum 25(OH)D3 concentrations were lower in adult asthma patients compared to the reference values in healthy adults.In patients underwent bronchial provocation test,positive correlation was found between PD20MCH-FEV1 and serum 25(OH)D3(r=0.73,P<0.01).In patients underwent bronchial relaxation test,serum 25(OH)D3 concentrations were positively correlated with both increase in FEV1 and increase in FEV1 ratio(r=0.53 and 0.59,respectively,P<0.01).Conclusions In adult asthma,serum 25(OH)D3 concentration is lower than the reference values in healthy adults,and related negatively with airway hyperresponsiveness(AHR),and positively with the improvement of airway obstruction in patients received with β2 receptor agonist.
Chinese Journal of Asthma(Electronic Version)
25hydroxy vitamin D3
Bronchial provocation test
Bronchial relaxation test