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大孔孔径对含CO3^2-的双相HA/β-TCP多孔陶瓷表面类骨磷灰石形成的影响 预览 被引量:4

Study of the effect of macropore diameter on the formation of the bone-like apatite in the carbonate-contained HA/β-TCP ceramics
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摘要 钙磷陶瓷植入生物体内后其表面首先形成一层含CO3^2-的类骨磷灰石层。它对钙磷陶瓷诱导新骨的生成起非常重要的作用。本文以模拟体液SBF9^#为介质。利用体外模拟装置首次研究了以新工艺制备的含CO3^2-的双相HA/β-TCP多孔陶瓷其大孔孔径对表面类骨磷灰石形成的影响。结果表明该陶瓷因CO3^2-的掺入导致类骨磷灰石晶体的形成时间大大缩短(从14d缩短至6d)。且以300~400μm的大孔孔径最有利于类骨磷灰石晶体的形成。此外还有缺钙羟基磷灰石晶体的生成。而最不利于类骨磷灰石晶体形成的大孔孔径为400~500μm。大孔孔径的优化有利于该陶瓷材料骨诱导性的提高,进而有利于骨缺损的快速修复。 The formation of the bone-like apatite containing carbonate has been deeply believed to provide the favorable environment for the new bone growth. At present, many researches have been carried out to study the calcium phosphate ceramics without carbonate. There have been few researches to focus on the carbonate-contained calcium phosphate ceramics, especially on the carbonate-contained HA/β-TCP. In this paper, the effect of the macropore diameter on the formation of the bone-like apatite in the carbonate-contained HA/β-TCP porous ceramics was discussed in detail for the first time. The results have shown that the bone-like apatite crystals can be formed in the surface and on the pore wall of this ceramics in shorter time (about 6days). And the 300~400μm macropore diameter favored the formation of the bone-like apatite crystals. The crystals were identified as the B-substituted bone-like apatite and calcium-lacked hydroxyapatite, which is beneficial to the osteoinductivity of the material. The optimization of the macropore diameter was advantageous to improving the osteoinductivity of the carbonate-contained HA/β- TCP porous ceramics, which was great help to the restoration of the bone defect.
作者 卢晓英 冉均国 苟立 孙璐薇 LU Xiao-ying~1, RAN Jun-guo~2, GOU Li~2, SUN Lu-wei~2 (1.School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 600031, China; 2. Department of Inorganic Material, Sichuan University, Chengdu 610065,China)
出处 《功能材料》 EI CAS CSCD 北大核心 2004年第4期 517-519,526,共4页 Journal of Functional Materials
基金 国家重大基础研究资助项目(973G1999064760)
关键词 大孔孔径 CO3^2- 钙磷陶瓷 类骨磷灰石 macropore diameter carbonate calcium phosphate ceramics bone-like apatite
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