期刊文献+

番茄红素抗癌作用的研究及进展 预览 被引量:15

LYCOPENE ON CANCER PREVENTION
在线阅读 下载PDF
收藏 分享 导出
摘要 番茄红素系烃类类胡萝卜素,具有抗癌和降低癌症发病几率的功能,尤其是胃肠道癌和前列腺癌.目前,流行病学通过对照研究发现,番茄红素主要通过对单线态氧的猝灭作用和诱导细胞间隙连接通讯等机制来抑制癌细胞的生长,使癌症的危险性与其摄入呈负相关.本文就番茄红素的抗癌作用从其分子结构、代谢分布、作用机制和细胞分裂等方面进行研究. Lycopene is hydrocabron carotenoid, having an inverse correlation between the consumption of tomato products and the risk of cancer, especially the gastrointestinal cancer and prostate cancer. Currently, the epidemiological contrast research indicate that the Lycopene in tomato inhibit the growth of the cancer cell primarily through removing the single line state oxygen and the mechanism of Gap Junctional Internetcellular Communication(GJIC) etc. and make the risk of the cancer with its obtaining negative related. The biological features of Lycopene, such as molecular structure, metabolism, tissue distribution and its anti - cancer function, possible mechanism and cell division are researched.
作者 蔡乐波 CAI Lebo Food Science and Technology, Hangzhou University of Commerce, 310035
出处 《食品研究与开发》 CAS 2004年第4期 6-10,共5页 Food Research and Developent
关键词 番茄红素 抗癌作用 胃肠道癌 前列腺癌 类胡萝卜素 作用机制 细胞分裂 Lycopene gastrointestinal cancer prostate cancer
  • 相关文献

参考文献20

  • 1Forssberg A, Ligen C, Ernster L, et al. Modification of the X- irradiation syndrome by lycopene. Exp Cell Res, 1959, 16:7- 14 被引量:1
  • 2Weststrate JA, van het Hof K. Sucrose polyester and plasma carotenoid concentrations in healthy subjects. Am J Clin Nutr,1995, 62:591 - 597 被引量:1
  • 3Brady WE, Mares - Periman JA, Bowen P, et al. Human serum carotenoid concentrations are related to physiologic and lifestyle factor. J Nutr, 1996, 126: 129- 137 被引量:1
  • 4Olmedilla B, Granado F, Bianco I, et al. Seasonal and sex - related variations in six serum carotenoids, retinol, and a tocopherol. Am J Clin Nutr, 1994, 60: 106- 110 被引量:1
  • 5Khacik F, Spangler Cj, Smith JC, et al. Identification,quantification and relative concerntrations of carotenoids, their metabolites in human milk and serum. Anal Chem, 1997, 69:1873- 1881 被引量:1
  • 6Ohigashi H, Osawa T, Teraao J, et al. Food factors for cancer Prevention. Tokyo. Springer, 1997 被引量:1
  • 7Petra Rus, Ppetra lehner. Relationship between dietary intake, antioxidant status and smoking habits in female Austrian smokers. Ejon, 2001,4:78- 83 被引量:1
  • 8Metha PP, et al. The actionsofretinoidson celluar growth correl at ewithhei raction songap junctional communition. J. Cell.Biol. 1989,108: 1053- 1065 被引量:1
  • 9Nagasawa H, Mitamura T, Sakamoto S, et al. Effects of lycopene on spontaneous mammary tumor development in SHM vergin mice. Anticancer Res, 1995, 15: 1173- 1178 被引量:1
  • 10Sharoni Y, Giron E, Rise M, et al. Effecets of Lycopeneenriched tomato. Cancer Detect Preve, 1997, 23:118- 123 被引量:1

二级参考文献9

  • 1王强.类胡萝卜素增强细胞间隙连接通讯与抑制细胞的恶性转化[J].生物化学与分子生物学动向,1997,3(1):39-41. 被引量:1
  • 2林仲翔.黄莞花提取物对V79细胞和WB肝细胞的生物学效应-细胞连接通讯与增殖活性的相关性变化[J].实验动物学报,1991,24(4):307-315. 被引量:1
  • 3[1]Werner R,Loewenstein WR,Birgit R.The cell-cell channel in the control of growth.Cell Biology,1992;3:59~79. 被引量:1
  • 4[2]Buch RJ.The role of gap junctional intercellular communication in neoplasia.Annal of Clinical Laboratory Science,1994:24(3):216~231. 被引量:1
  • 5[3]Bertram JS,Bortkiewicz H.Dietary carotcnoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells.Am J Clin Nutr.1995;62:1327s~1336s. 被引量:1
  • 6[4]Pung A,Rundhang JE,Yoshizawa CN,et al.β-Carotene and canthaxathin inhibit chemically and physically induced neoplastic transformation in 10T1/2 cells.Carcinogenesis,1988,9:1533~39. 被引量:1
  • 7[5]Loewenstein W.Junctional intrcellular communication and control of growth.Biochem.Biophys.Acta,1979;560:1~65.. 被引量:1
  • 8赵文恩,韩雅珊,SaiShi Hirota,苏震,张仲纶,郑雁珍,.类胡萝卜素对H2O2—NaOCl体系生成的^1O2的猝灭作用[J].生物物理学报,1997,13(1):137-142. 被引量:37
  • 9王强,韩雅珊.天然类胡萝卜素抑制细胞恶性转化机理的初步研究[J].食品科学,2000,21(12):46-47. 被引量:10

共引文献18

同被引文献148

引证文献15

二级引证文献69

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈