期刊文献+

正常促性腺激素妇女垂体降调节后晚卵泡期黄体生成素浓度对体外受精结局的影响 预览 被引量:11

Effect of Concentration of Circulating Luteinizing Hormone in Late-follicle Phase on the Outcome of in vitro Fertilization for Normogonadotrophic Women
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:探讨正常促性腺激素妇女超促排卯时晚卵泡期黄体生成素(LH)水平对体外受精(IVF)结局的影响.方法:正常促性腺激素妇女432个周期,于黄体中期开始采用促性腺激素释放激素激动剂(GnRHa)行垂体降调节后,应用卵泡刺激素(FSH)刺激卵巢的促排卵方案.当卵泡直径达14 mm时,添加hMG(FSH+hMG组),对照组不添加hMG(FSH组).hCG注射日测定血LH和雌二醇(E2)浓度.按照LH浓度,将FSH+hMG组分为4个亚组.结果:FSH+hMG组的hCG注射日E2浓度高于FSH组[(3 435.51±2 029.01)pg/ml和2 620.62±1 604.80)pg/ml,P<0.05],胚胎移植数少于后者[(2.77±0.45)个和(2.22±0.46)个,P<0.001].两组受精率、胚胎种植率和临床妊娠率无统计学差异(77.52%和78.31%,41.42%和41.68%,64.56%和62.64%,P均>0.05);FSH+hMG组的4个亚组的受精率、胚胎种植率和临床妊娠率也无统计学差异(P>0.05).结论:正常促性腺激素妇女超促排卯时,晚卵泡期血清LH在生理范围内以及在晚卵泡期适量添加LH,不会对IVF结局产生负面影响. Objective: To evaluate the impact of the concentration of circulating luteinizing hormone (LH) in the late-follicle phase on the outcome of in vitro fertilization for normogonadotrophic women. Methods: Intracytoplasmic sperm injection treatment was conducted in 432 consecutive cycles of normogonadotrophic women. A stimulation protocol with mid-luteal gonadotropin-releasing hormone (GnRH) agonist down-regulation and ovarian stimulation with follicle stimulating hormone (FSH) was used in all cycles. hMG was added when a follicle of ≥14 mm was present (FSH+hMG group), not in the control group (FSH-alone). LH and oestradiol concentration in the serum on hCG day were detected. Based on LH levels, patients in the FSH+hMG group were again divided into four subgroups: LH≤1, 1<LH≤2, 2<LH≤3, and 3<LH≤10 IU/L. Results: Oestradiol concentration on the day of hCG injection in the FSH+hMG group was higher than that in the FSH-alone group [( 3 435.51± 2 029.01) pg/ml vs ( 2 620.62± 1 604.80) pg/ml, P< 0.05]. More embryos were transferred in the FSH-alone group than in the FSH+hMG group[( 2.77± 0.45) vs ( 2.22± 0.46), P< 0.001). Fertilization rate, implantation rate, and clinical pregnancy rate were similar between the FSH-alone group and the FSH+hMG group ( 77.52% vs 78.31%, 41.42% vs 41.68%, 64.56% vs 62.64%, P> 0.05), as well as among the four subgroups of the FSH+hMG group (P> 0.05). Conclusion: The adding of suitable amount of hMG and physiologically limited LH concentration in the late-follicle phase have no negative effect on the outcome of in vitro fertilization/intracytoplasmic sperm injection for normogonadotrophic women.
作者 孙海翔 胡娅莉 王玢 陈骞 张宁媛 陈华 王俊霞 徐志鹏 Sun Haixiang, Hu Yali, Wang Bin, Chen Qian, Zhang Ningyuan, Chen Hua, Wang Junxia, Xu Zhipeng Reproductive Medicine Center, Drum Tower Hospital Affiliated to Nanjing University Medical College, Nanjing, Jiangsu 210008,China(Sun HX, Hu YL, Wang B, Chne Q, Zhnag NY, Chen H, Wang JX, Xu ZP)
出处 《中华男科学杂志》 CAS CSCD 2004年第12期 912-915,共4页 National Journal of Andrology
关键词 超促排卵 黄体生成素 体外受精 superovulating luteinizing hormone in vitro fertilization
  • 相关文献

参考文献6

  • 1Coppola F, Poti ER, Barusi L, et al. Profound luteinizing hormone suppression induces a deleterious follicular environment during assisted reproductive technology[J]. Fertil Steril, 2003, 79(2) :459-460. 被引量:1
  • 2European Recombinant Human LH Study Group. Recombinmnt human luteinizing hormone (LH) to support recombinant human follicular stimulating hormone ( FSH ) -induced follicular development in LH-and FSH-deficient anovulatory women: a dose-finding study [ J ]. J Clin Endocrinol Metab, 1998, 83 ( 5 ): 1507-1514. 被引量:1
  • 3Balasch J, Vidal E, Penarrubia J, et al. Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH [ J ].Hum Reprod, 2001, 16(8) :1636-1643. 被引量:1
  • 4Westergaard LG, Laursen SB, Andersen CY. Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction [ J]. Hum Reprod, 2000, 15(5) :1003-1008. 被引量:1
  • 5Regan L, Owen E J, Jacobs HS. Hyperseeretion of luteinising hormone, infertility, and miscarriage [ J]. Lancet, 1990, 336(8724) :1141-1144. 被引量:1
  • 6Filicori M. The role of luteinizing hormone in folliculogenesis and ovulation induction[J]. Fertil Steril, 1999, 71 (3) :405-414. 被引量:1

同被引文献123

引证文献11

二级引证文献58

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈
新型冠状病毒肺炎防控与诊疗专栏