期刊文献+

血清CA125在卵巢癌诊断中的价值及文献评价 预览 被引量:35

Evaluation of serum CA125 in literatures of ovarian neoplasms based on evidence-based medicine
在线阅读 下载PDF
分享 导出
摘要 目的对血清癌胚抗原(CA)125测定在卵巢癌诊断中的价值进行评价.方法参照诊断性试验的评价指标,对文献的设计方案、研究对象的选择、参考值的确立、诊断试验的评价指标等进行评价.结果纳入的63篇文献中有62篇与金标准进行了比较,但未提及是否采用盲法;所提供的诊断性指标(敏感度、特异度、似然比等)不全面,对偏倚的控制没有描述,对采用同一种方法测定的研究文献,其所得结论不完全相同.结论提示目前尚无临床证据表明CA125可作为诊断卵巢癌的独立指标. Objective To assess the serum CA125 in literatures of ovarian neoplasms based on evidence-based medicine.Methods The relating reports published in the years of 1996—2003 were collected and evaluated according to the evidence-based medicine principles. Main outcomes include design methods,sample screening,establishment of control group,blind method,criteria of diagnostic trials.Results In the reports collected, gold standard was adopted in 62 reports and independent blind method was adopted in 23 reports, criteria of diagnostic trials such as sensitivity, specificity and likelihood ratio were incomplete and there was no descriptions okf potential bias controlling. As for the literatures sharing the same method ,their conclusion did not totally accord with each other.Conclusion There is no evidence to implicate that serum CA125 was considered an independent predictor of the diagnosis of ovarian cancer.
作者 李山 秦雪 何卫华 LI Shan*,QIN Xue,HE Wei-hua .*Department of Clinical Laboratory , The First Affiliated Hospital of Guangxi Medical University , Nanning 530021,China
出处 《中华检验医学杂志》 CAS 北大核心 2005年第2期 209-211,共3页 Chinese Journal of Laboratory Medicine
关键词 诊断性试验 卵巢癌 血清CA125 文献评价 盲法 特异度 金标准 结论 参照 评价指标 CA125 antigen Ovarian neoplasms Evidence-based medicine
  • 相关文献

参考文献6

二级参考文献20

  • 1陶晓靖.卵巢恶性上皮性肿瘤标记物及其临床应用[J].重庆医学,1994,23(1):49-52. 被引量:1
  • 2Malkasaian RF, Karathas P, Berg P, et aL Pretreatment serum levels of CA125 carcinoembyronic antigen tissue polypeptide antigen, and placental alkaline phosphatase in-patients with ovarian carcinoma broderline tumors or benign adnexalmasses: relevance for differential diagnosis[J]. Cancer, 1995,39 : 16. 被引量:1
  • 3林巧稚.妇科肿瘤学[M].北京:人民卫生出版社,1994.458. 被引量:5
  • 4王觉生.诊断性试验证据的严格评价[M]。见:王家良主编 21世纪的临床医学-循证医学 北京:人民卫生出版社2001:62-73. 被引量:2
  • 5Elmore J G, Boyko E J. Assessing accuracy of diagnostic and screening tests.In: Geyman J P,Deyo R A.Scott D.Ramsey S D ,eds.Evidence-Based Clinical Practice:Concepts and approaches[M]。Boston ButterworthHeinemann,2000:83-93. 被引量:1
  • 6Sackett D L,Straus S E,Richardson W S,et al.Diagnosis and screening. In: Sackett D L,Straus S E ,Richardson W S,eds.Evidence-based Medicine:How to practice and teach EBM[M]. London:Churchill Livingstone,2000:67-93. 被引量:1
  • 7Van Nagell JR.Ovarian cancer screening[].Cancer.1991 被引量:1
  • 8Ind TEJ,Iles RK,De Souzak,et al.Serum placental-typealkaline phosphatase levels in patients with epithelial ovarian carcinoma[].International Journal of Oncology.1995 被引量:1
  • 9MutoMC,CramerDW,BrownDL,etal.Screningforovariancancer:Thepreliminaryexperienceofafamilialovariancan cercentre〔J〕[].Gynecologic Oncology.1993 被引量:1
  • 10WoolasRP,XuFJ,JacobsIJ,etal.ElevationofmultipleserummarkersinpatientswithstageⅠovariancancer〔J〕[].JNatlCancerInst.1993 被引量:1

共引文献36

同被引文献302

引证文献35

二级引证文献118

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈