期刊文献+

大鼠增龄中胰腺超微结构的变化及胰岛的分布规律 被引量:5

Changes of the ultrastructure of pancreas and distributive pattern of islet in rats with age
在线阅读 免费下载
分享 导出
摘要 目的探讨胰腺超微结构的增龄变化及胰岛的分布规律,以提供胰腺移植的参考.方法取30只健康SD大鼠,分3组,幼年、青年、老年各10只,每只取胰头、体、尾做组织切片光镜观察.每组选3只取胰尾做透射电镜观察.结果透射电镜观察老年鼠胰腺外分泌部的腺细胞,胞核固缩,酶原颗粒减少,线粒体脱嵴肿胀,粗面内质网扩张,出现脂滴,溶酶体增多,而内分泌部的B细胞分泌颗粒空晕增宽,数量减少,粗面内质网脱粒,线粒体减少.A细胞无明显年龄变化.光镜观察老年鼠胰腺小叶间结缔组织增生,胰岛的分布以幼鼠胰尾数量为多.结论胰腺外分泌部的腺细胞和内分泌部的B细胞呈现与年龄相关的结构变化,胰岛的分布以幼鼠胰尾的胰岛数目为最多.提示胰腺移植的供体以幼年胰尾为佳,老年不宜. Objective To study the changes of the ultrastructure of pancreas and distributive pattern of islet with age, to supply reference for the pancreas transplantation. Methods 30 healthy SD rats were divided into 3 groups: young group, adult group and aged group, 10 rats each group. The pancreas heads, body and tail of each rat were removed to make tissue slice for observation with light microscope. Pancreas tails of 3 rats selected from each group were removed for observation with transmission electron microscope. Results TEM showed that in aged rats, the nucleus of their gland cell of the exo-crine portion became pyknotic, the zymogen granules were reduced, the mitochondria were hypertrophic and their cristae fell off, the rough endoplasmic reticula were dilated, the adipose drops appeared and the lysosomes were increased. But, in the endocrine portion, the halo of secretory granules in the B cell were increased in width, reduced in number, the granules of rough surfaced endoplasmic reticulum fell off and the mitochondria were reduced. In A cell no obvious changes occurred with age. The aged rats were observed by LM and the connective tissues between the lobular pancreatises were hyperplastic. The distribution . of pancreas islet was large in number in pancreatic tail of young rat. Conclusion The gland cell of exocrine and the B cell of endocrine of pancreas occurred in the structural change correlated to the age. The distribution of pancreas islet was large in number in pancreatic tail of young rat. It is suggested that in the donor for pancreas transplantation the tail from young rat is preferable to that of the aged.
作者 陈群 李良庆 陈少强 Cheng qun ,Lee liang-qing,Cheng shou-qiang (Department of General Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou 350004 Department of Anatomy, Fujian Medical University)
出处 《四川解剖学杂志》 2005年第2期 11-14,共4页 Sichuan Journal of Anatomy
关键词 大鼠 胰腺 超微结构 胰岛 rat pancreas ultrastructure pancreas islet
  • 相关文献

参考文献8

二级参考文献1

  • 1G. Gold,G. M. Grodsky. Kinetic aspects of compartmental storage and secretion of insulin and zinc[J] 1984,Experientia(10):1105~1114 被引量:1

共引文献37

同被引文献99

引证文献5

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈