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配合物[Pd(L-tyr)2]·0.5H2O的晶体结构、稳定性及其与DNA作用研究 预览 被引量:5

Study on Crystal Structure, Stability and the Interaction of Complex [Pd(L-tyr)2]·0.5H2O with DNA
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摘要 合成了配合物[Pd(L-tyr)2]·0.5H2O单晶(L-tyr-为酪氨酸根).配合物属于单斜晶系,P2(1)空间群.L-tyr-的羧基氧原子和氨基氮原子与Pd(Ⅱ)离子配位,形成两个五元螯合环的平面结构.配合物分子之间存在配位螯合环-配位螯合环的弱相互作用、苯酚环-苯酚环之间的π-π堆积作用以及水分子与配体之间的氢键作用.水溶液中配合物的累积稳定常数为1017数量级,表明配体与离子形成较强的配位共价键.配合物与鱼精DNA作用的紫外光谱、CD光谱和荧光光谱表明,两者之间有较强的相互作用,并以插入作用方式为主. A single crystal of [Pd(L-tyr)2]?0.5H2O was synthesized, and it belongs to monoclinic system with space group P2(1). Oxygen atom of carboxyl and nitrogen atom of azyl coordinate with Pd(II) ion to form two planar five-membered rings. There were weak interaction between one coordinate chelate ring and another coordinate chelate ring, π-π stacking between phenolic rings and hydrogen bonds between water molecule and ligand. In water solution, cumulative stability constant β2 of title complex is 1017, and it means that there was strong coordinate-covalent bond between ligand and Pd(II) ion. The interaction of the com- plex with fish sperm DNA has been studied by UV, fluorescence and CD. The results show that the interac- tion of the complex with DNA took mainly insertion mode and there was strong interaction between com- plex and DNA.
作者 高恩君 李浩洋 刘祁涛 GAO, En-Jun* ,a LI, Hao-Yang a LIU, Qi-Tao b (a Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142) (b Institute of Chemical Science and Engineering, Liaoning University, Shenyang 110036)
出处 《化学学报》 SCIE CAS CSCD 北大核心 2005年第13期 1225-1230,i004,共7页 Acta Chimica Sinica
基金 沈阳化工学院校科研和教改项目,辽宁省自然科学基金
关键词 钯配合物 晶体结构 稳定性 DNA 氢键 插入作用方式 抗肿瘤活性 palladium(II) tyrosine structure stability constant DNA
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