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中国3岁以上人群乙型肝炎血清流行病学研究 被引量:933

A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old
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摘要 目的了解中国现阶段乙型肝炎(乙肝)病毒(HBV)感染现状和评价自1992年乙肝疫苗纳入儿童免疫策略所取得效果.方法利用中国疾病预防控制中心"2002年中国居民营养与健康状况调查"保留的血清开展乙肝血清学检测.以美国Abbott乙肝酶联免疫吸附试验(ELISA)试剂为金标准选择中国乙肝ELISA检测试剂,并用固相放射免疫方法校对检测结果.结果中国≥3岁人群HBsAg阳性率、抗-HBs阳性率、HBV流行率经调整后分别为9.09%、37.48%、50 04%;3~12岁儿童分别为5.03%、45 33%、29.10%.≥3岁城市人群HBsAg阳性率、HBV流行率分别为4 61%、43 51%,农村人群分别为9.41%、56 77%.3~12岁城市儿童HBsAg阳性率、HBV流行率分别为2.10%、20.45%,农村儿童分别为8.25%、39.22%.结论中国≥3岁人群乙肝流行病学特征已发生改变,乙肝疫苗纳入儿童免疫规划效果显著,人群HBsAg阳性率、HBV流行率均有不同程度下降,3~12岁儿童下降更为明显. Objective To better understand and measure the impact from immunization activities over the last 10-years, we conducted a sero-epidemiological study using the remaining blood samples of a nationwide survey on Nutrition and Health in Chinese residents, in 2002. Methods HBsAg, anti-HBs and anti-HBc in blood samples were tested using enzyme-linked immunosorbent assay(ELISA) reagents and revised by solid phase radioimmunoassay and Abbott ELISA reagents. Results Among population older than 3 years, the prevalence rates of HBsAg, anti-HBs and hepatitis B virus(HBV) infection were 9.09 % , 37.48% and 50.04% but for children between 3 and 12 year olds, they were 5.03%, 45.33% and 29.10% respectively. Among population older than 3 years, the rates of HBsAg and HBV infection in urban area were 4.61% and 43.51%, but the rates in rural area were 9.41% and 56.77% respectively while for children from 3-years to 12-years old, they rates were 2.10%, 20.45% in urban area and 8.25%, 39.22% in rural areas, respectively. Conclusion Results revealed that since the hepatitis B vaccine was introduced into the expanded program on immunization(EPI) from 1992, the prevalence rates of HBsAg and HBV infection, especially in the children from 3 to 12 years of age, had obviously declined, suggesting that some changes had happened in the epidemic characters of hepatitis 13 in China.
作者 梁晓峰 陈园生 王晓军 贺雄 陈丽娟 王骏 林长缨 白呼群 严俊 崔钢 于竞进 Liang XiaoFeng;Chen YuanSheng;Wang XiaoJun;He Xiong;Chen LiJuan;Wang Jun;Lin ChangYing;Bai HuQun;Yan Jun;Cui Gang;Yu JingJin
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2005年第9期 655-658,共4页 Chinese Journal of Epidemiology
基金 中国药品生物制品检定所为本次乙肝血清学检测免费提供试剂质控品 实验室检测得到中国工程院院士、北京大学医学部庄辉教授和中国肝炎基金会诸多专家的支持与指导 并得到中国疾病预防控制中心病毒病预防控制所、营养与食品安全所和公共卫生监测与信息中心诸多专家与领导的支持,一并致谢
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