期刊文献+

肿瘤增殖抗原Ki67和抑癌基因P16在肾上腺皮质肿瘤组织中的表达及意义 预览 被引量:7

Significance of expressions of Ki67 and P16 in adrenocortical tumor tissue
在线阅读 下载PDF
分享 导出
摘要 目的联合检测肿瘤增殖抗原Ki67和抑癌基因P16在肾上腺皮质肿瘤中的表达,探讨Ki67及P16与肾上腺皮质肿瘤的关系.方法应用免疫组化方法检测45例肾上腺皮质肿瘤(腺瘤39例、腺癌6例)及9例瘤旁正常组织标本中Ki67及P16的标记指数(LI).结果 Ki67在正常肾上腺组织不表达,在腺癌表达最高,腺瘤次之;P16在正常肾上腺组织表达最高,腺瘤次之,腺癌最低,Ki67和P16在肾上腺皮质恶性肿瘤表达的结果与良性肿瘤表达的结果相比较差异有统计学意义(均P<0.01),且存在负相关关系(r=-0.67,P<0.05).Ki67的LI在肾上腺皮质腺瘤、腺癌的界定值为4%;P16的LI在肾上腺皮质腺瘤、腺癌的界定值为12%.结论 Ki67及P16的表达与肾上腺肿瘤显著相关,Ki67的LI>4%和P16的LI<12%时,提示为腺癌.联合检测Ki67和P16在肾上腺皮质肿瘤的表达对鉴别良、恶性肾上腺皮质肿瘤具有重要的参考意义. Objective To study the relationship between Ki67、 P16 and adrenocortical tumors by combining assays of expressions of Ki67 and P16 in adrenocortical tumor. Methods The labeling indexes (LI) of Ki67 and P16 were detected by immunohistochemical staining in 6 cases of adrenocortical carcinoma, 39 cases of adrenocortical adenoma and 9 cases of normal adrenocortical tissue beside the tumor. Results The highest expression of Ki67 and the lowest expressions of P16 were found in adrenocortical carcinoma. There existed negative correlation between the expressions of Ki67 and P16 ( r = - 0.67, P 〈 0.05). There was significant difference in the LI of Ki67 and P16 between adrenocortical carcinoma and adrenocortical adenoma (both P 〈 0.01) , with LI eutpoints of 4% and 12% respectively. Conclusion The LI of Ki67 above 4% and LI of P16 below 12% may indicate adrenocortical carcinoma. It is suggested that combined detections of Ki67 and P16 may have reference significance in the differentiation of adrencortical adenoma from adrencortical carcinoma.
作者 卢德成 罗佐杰 冼晶 韦敏怡 闭慎金 LU De-cheng, LUO Zuo-jie, XIAN ring, WEI Min-yi, BI Shen-jin. (Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021)
出处 《中华内分泌代谢杂志》 CAS 北大核心 2005年第5期 412-415,共4页 Chinese Journal of Endocrinology and Metabolism
关键词 肿瘤增殖抗原Ki67 抑癌基因P16 肾上腺皮质肿瘤 肿瘤组织 基因表达 鉴别诊断 免疫组织化学 Adrenocortical tumor Immunohistochemistry Ki67 antigen P16 protein
  • 相关文献

参考文献9

二级参考文献18

共引文献35

同被引文献53

引证文献7

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈