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探讨CDX2在胃肠道腺癌诊断中的病理学价值 预览 被引量:5

Role of CDX2 immunostaining in diagnosis of gastrointesfisml adenocarcinom
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摘要 目的观察CDX2在多种正常组织和肿瘤组织中的表达特点,探讨CDX2在胃肠道腺癌诊断中的病理学价值。方法采用组织芯片和免疫组织化学(EliVision)方法,对CDX2在76例正常组织和612例肿瘤组织(结肠癌、胃癌、肝癌、前列腺癌、肾细胞癌、乳腺癌、肾上腺腺癌、淋巴瘤、肺癌等)中的表达特点进行分析。结果CDX2在13例正常肠道上皮、8例胰腺小导管上皮中呈强阳性表达;在47例(92.2%)结肠腺癌组织、58例(66.9%)胃癌组织中呈强阳性表达;在其他少数肿瘤组织中呈弱阳性或散在阳性,其阳性率分别是卵巢黏液癌10/64、胰腺肿瘤3/9、甲状腺癌3/11、肝外胆道系统肿瘤4/16;在乳腺、前列腺、肾、肾上腺、肝等正常组织和肿瘤组织中未见CDX2表达。结论CDX2主要在正常肠道、胰腺小导管上皮和胃肠道肿瘤中表达,少数其他部位的上皮性肿瘤也有CDX2的表达,但表达特点与在胃肠道肿瘤不同。因此CDX2在鉴别原发癌和转移癌时具有一定的参考价值。 Objective To study the expression of CDX2 in normal and tumor tissues, and to evaluate the value of CDX2 immunostaining in the diagnosis of gastrointestinal edenecareinoma. Method Seventy-six samples of normal tissue and 612 samples of tumor tissue were studied by tissue microarray technology and immunohistechemistry for CDX2. Results CDX2 was strongly expressed in surface epithelium of 13 samples of normal intestine and in ductai epithelium of 8 samples of normal pancreas, as well as in 47 samples ( 92. 2% ) of colonic edenecareinoma and 58 samples ( 66. 9% ) of gastric edenecarcinoma. As for other tumor types, there was only weak or patchy CDX2 positivity. The positivity rates were as follows: ovarian mucinous adenocareinoma 15.6% ( 10/64), pancreatic cancer 33. 3% (3/ 9), thyroid cancer 27.3% (3/11) and extrahepatic biliary cancer 25% (4/16). On the other hand, primary tumors of breast, prostate, kidney, adrenal and liver were negative for CDX2. Conclusions CDX2 is expressed mainly in normal epithelium of intestinal tract and small pancreatic ducts, as well as in primary edenocarcinoma of gastrointestinal tract. CDX2 may thus play an important role in distinguishing primary non-intestinal adenecarcinoma from metastatic adenecarcinoma of gastric or colorectai primary.
作者 王超 周小鸽 WANG Chao,ZHOU Xiao-ge.(Department of Pathology, Beijing Friendship Hospital of the Capital University of Medicine Science, Beijing 100050, China)
出处 《中华病理学杂志》 CAS 北大核心 2006年第4期 228-231,共4页 Chinese Journal of Pathology
关键词 抗体 肿瘤 胃肠肿瘤 免疫组织化学 Antibodies,neoplasm Gastrointestinal neoplasms Immunohistochemistry
作者简介 通信作者:周小鸽
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参考文献28

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