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新型双核配合物的形成、与DNA的作用机制及荧光性质研究 预览 被引量:20

Studies on the Formation, DNA-Binding and Luminescent Properties of New Heterobimetallic Complexes
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摘要 利用紫外、荧光和粘度等方法研究了含不同配体的钌(Ⅱ)配合物[Ru(phen)2CImP]^2+(CImP=3,4-二羟基-咪唑并[4,5-i][1,10]邻菲咯啉)和[Ru(phen)2TPPZ]^2+(TPPZ=四吡啶[3,2-a:2',3'-c:3",2"-h:2"',3"'-j]吩嗪)与DNA的作用机制,并研究了配合物与Zn2+配合后荧光性质变化.结果表明[Ru(phen)2TPPZ]^2+与DNA以插入模式作用,而[Ru(phen)2CImP]^2+与DNA则以沟面结合模式作用.向配合物溶液中滴加Zn2+后,配合物[Ru(phen)2TPPZ]^2+和[Ru(phen)2CImP]^2+均可以与Zn^2+形成双核配合物[Ru(phen)2(TPPZ)Zn]^4+和[Ru(phen)2(CImP)Zn]^4+,配合物的荧光减弱.与DNA作用后,配合物仍可以与Zn^2+配位形成双核配合物,但[Ru(phen)2(TPPZ)Zn]^4+保持插入模式与DNA作用,配合物的荧光减弱.而[Ru(phen)2(CImP)Zn]^4+与DNA则由沟面结合改为插入结合,配合物的荧光增强. The binding modes of polypyridyl 3,4-dihydroxyl-imidazo[4,5-i](1,10-phenanthroline) ruthenium(II) complexes [Ru(phen)2CImP]^2+ (CImP: and [Ru(phen)2TPPZ]^2+ (TPPZ: tetrapyrido[3,2-c:2', 3'-e:3",2"-j:2'",3'"-l]phenazine) with calf thymus DNA have been investigated by spectroscopic and viscosity methods. The luminescent properties of coordinated complexes with Zn^2+ were also studied. The experimental results indicated that [Ru(phen)2TPPZ]^2+ bound to DNA by intercalation, while [Ru(phen)2CImP]^2+ bound to DNA by groove binding mode. Both complexes could be coordinated with Zn^2+ to form the heterobimetallic complexes [Ru(phen)2(TPPZ)Zn]^4+ and [Ru(phen)2(CImP)Zn]^4+, and the emission intensity of complexes decreased with increasing the amount of Zn^2+. After binding to DNA, both original complexes could be coordinated with Zn^2+ to form the heterobimetallic complexes, and [Ru(phen)2(TPPZ)Zn]^4+ kept binding to DNA by intercalation, with the emission intensity decreased, while the binding mode of [Ru(phen)2(CImP)Zn]^4+ was changed from groove binding to intercalation, with increase of the emission intensity.
作者 张黔玲 刘剑洪 任祥忠 张培新 李翠华 王芳 徐宏 刘建忠 计亮年 ZHANG Qian-Ling,LIU Jian-Hong,REN Xiang-Zhong,ZHANG Pei-Xin,LI Cui-Hua, WANG Fang,XU Hong,LIU Jian-Zhong,JI Liang-Nian( 1. Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen 518060;2. The Key Laboratory of Gene Engineering of Ministry of Education of China, Zhongshan University, Guangzhou 510275;3 School of Materials Science and Engineering, Xi'an University of Architecture and Technology, Xi'an 710055)
出处 《化学学报》 SCIE CAS CSCD 北大核心 2006年第10期 968-974,共7页 Acta Chimica Sinica
基金 广东省自然科学基金博士启动基金(No.04300882)和深圳市科技计划(No.200328)资助项目.
关键词 多吡啶钌(Ⅱ)配合物 DNA Zn2+ 荧光 插入结合 polypyridyl ruthenium(Ⅱ) complex DNA zinc(Ⅱ) luminescence intercalation
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