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TiO2纳米颗粒对钌(Ⅱ)三联吡啶配合物光损伤小牛胸腺DNA能力的影响 预览 被引量:3

Effects of TiO2 Nanoparticles on the Photodamage of CT-DNA by Ru(Ⅱ) Bis(terpyridine) Complexes
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摘要 由于极短的激发态寿命,钌(Ⅱ)三联吡啶配合物对脱氧核糖核酸(DNA)的光损伤能力低下.设计合成了三个钌(Ⅱ)三联吡啶配合物[Ru(tttp)(tpy)]^2+(1),[Ru(ttp-COOH)(tpy)]^2+(2)和[Ru(ttp—COOH)(tpy—pyr)]^2+(3),其中tpy为2,2':6’,2"-三联吡啶,ttp为4’-(4-甲苯基)-2,2’:6’,2"-三联吡啶,ttp—COOH为4’-(4-羧基苯基).2,2’:6’,2"-三联吡啶,tpy-pyr为4'-(1-芘基)-2,2’:6’,2”-三联吡啶.比较了TiO2纳米颗粒对它们光损伤小牛胸腺DNA的影响.发现TiO2纳米颗粒在空气和氩气条件下均可显著提高配合物3光损伤DNA的能力.Ti02纳米颗粒和配合物3间的光诱导电子转移作用及其该作用生成的钌(Ⅲ)物种可能是促进配合物3对DNA光损伤的主要原因. Due to their short excited state lifetimes, Ru(Ⅱ) bis(terpyridine) complexes can hardly used as DNA photocleavers. In this paper three Ru(Ⅱ) bis(terpyridine) complexes [Ru(ttp)(tpy)]2+ (1), [Ru(ttp- COOH)(tpy)]^2+ (2) and [Ru(ttp-COOH)(tpy-pyr)]^2+ (3) were designed and synthesized (tpy=2,2':6',2''- terpyridine, ttp = 4'-(p-tolyl)-2,2':6',2"-terpyridine, ttp-COOH = 4'-(p-carboxyl-phenyl)-2,2':6',2"-terpyridine, tpy-pry=4'-(l-pyrenyl)-2,2':6',2"-terpyridine). It was found that TiO2 nanoparticles improved the photodamage ability of 3 on calf thymus DNA in both aerated and deaerated conditions. The oxidized form of 3, [Ru(Ⅲ)(ttp-COOH)(tpy-pyr)]^3+, generated by photoinduced electron transfer between TiO2 nanoparticle and 3, was invoked to account for the enhanced DNA photodamage.
作者 丁慧颖 宋林青 陈景荣 王雪松 张宝文 DING, Hui-Ying SONG, Lin-Qing CHEN, Jing-Rong WANG, Xue-Song ZHANG, Bao-Wen (a Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101;b Graduate School of the Chinese Academy of Sciences, Beijing 100039)
出处 《化学学报》 SCIE CAS CSCD 北大核心 2006年第17期 1799-1804,共6页 Acta Chimica Sinica
基金 973(No.G2000028204)资助项目.
关键词 钌配合物 三联吡啶配体 二氧化钛纳米颗粒 光诱导电子转移 小牛胸腺DNA 光损伤 Ru(Ⅱ) complex terpyridine ligand TiO2 nanoparticle photoinduced electron transfer calf thymus DNA photodamage
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