期刊文献+

米氮平治疗帕金森氏病伴发抑郁焦虑 预览 被引量:1

Mirtazapine vs Flouxetine in treating Parkinson's disease With depressive and anxiety
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:比较米氮平与氟西汀治疗帕金森氏病伴发抑郁焦虑的疗效及不良反应。方法:67例帕金森氏病伴发抑郁焦虑病人,随机分2组。米氮平组34例,男22例,女12例;年龄45—73岁,平均(66.66±12.37)岁;给予米氮平30mg,po,qd,6W为一个疗程。氟西汀组33例,男23例,女10例;年龄41-72岁,平均(54.96±11.81)岁;给予氟西汀20mg,po,qd,6W为一个疗程。采用汉密顿抑郁量表(HAMD),汉密顿焦虑量表(HAMA),药物副反应量表(TESS)分别评定。结果:对抑郁症状的治疗,米氮平组显效率76,47%,氟西汀组显效率75.76%,疗效差异无显著性(P〉0.05);对焦虑症状的治疗,米氮平组显效率76.47%,氟西汀组显效率60.61%,疗效差异无显著性(P〉0.05)。药物不良反应发生率2组相当。结论:米氮平与氟西汀对帕金森氏病伴发抑郁焦虑安全有效。 Objective :To study clinical efficacy and safety of mina, pin and flouxetine in the Parkinson's disease (PD) with depression and anxiety. Methods:67 PD with depression and anxiety patients were randomly divided into two groups: mirtazapine group of 34 patients were treated with mirtazapine 30 mg/d, po, qd for six weeks, flouxetine group of 33 patients were treated with flouxetine 20 mg/d, po, qd for six weeks. Results: The marked effective rate of mirtazapine group and flouxetine group were 76.47% and 75.76% ( P 〉 0.05 ) in treating depression symptoms, but the marked effective rate of mirtazapine group and flouxetine group were 76.47% and 60.61% (P 〉 0.05 ) in treating anxiety symptoms. The adverse reactions in mirtazapine group and flouxetine group should no significant difference. Conclusions: mirtazapine shows same effective in treating PD with depression and anxiety compared to flouxetine.
作者 张留莎 陈佐明 张萍 ZHANG Liu - sha, CHEN Zuo - ming, ZHANG Ping (The Second Affiliated Hospital of Xinxiang Medical College, Xinxiang 453002, China)
出处 《中国民康医学》 2006年第23期 1000-1001,共2页 medical journal of chinese peoples health
关键词 帕金森氏病 抑郁焦虑 米氮平 氟西汀 Parkinson' s disease Depression and anxiety Mirtazapine Flouxetine
  • 相关文献

参考文献9

二级参考文献17

  • 1张振馨,洪霞,Roman GC.世界不同地区帕金森病的流行特征[J].中华流行病学杂志,1996,17(1):47-51. 被引量:12
  • 2汪向东.心理卫生评定量表手册[J].中国心理卫生杂志,1993,:202-209. 被引量:1894
  • 3王新德.帕金森病及帕金森综合征的诊断标准[J].中华神经精神科杂志,1985,18:256-256. 被引量:48
  • 4[1]Aarsland D,Tandberg E,Larsen JP,et al. Freguency of dementia in parkinson' s disease[J]. Arch Neurol, 1996,53: 538 ~ 742. 被引量:1
  • 5[2]Teffreg L. Cummings.Depression and parkinson's disease[J].Am J Psychiatry, 1992,149:443 ~ 453. 被引量:1
  • 6[3]Martila RJ. Diagnosis and epidemiology of parkinson' s disease [J] .Acta Neurol Sean,1983,9:9. 被引量:1
  • 7[4]Starkstein SE, Berthier ML, Bolduc PL, et al. Depression in patients with early versus late onset of parkinson' s disease[J] .Neurology, 1989,39:1441 ~ 1445. 被引量:1
  • 8[5]Elise Tandberg, Jan p. Larsen, Dag Aarsland et al. The occurrence of depressio is parkinson' s disease[J]. Arch Neurol, 1996,53:175 ~ 179. 被引量:1
  • 9[6]Richard Mayeux,Yaakov stern,Janet B.W.Williams,et al. Clinical and biochemical features of depression in parkinson' s disease [J]. Am J psychiatry, 1986,143:756 ~ 759. 被引量:1
  • 10[7]Brown GL, Wilson wp, Parkinsonism and depression [ J ]. South Med J, 1972,65:540 ~ 545. 被引量:1

共引文献58

同被引文献19

  • 1张菁,李舜伟.帕金森病伴发抑郁障碍的发病机制和药物治疗[J].北京医学,2005,27(8):499-501. 被引量:4
  • 2Cummings JL. Depression and Parkinson's disease: Areview[J]. Am J Psych larry, 1992,194(4):443. 被引量:1
  • 3Reijnders IS, Ehrt U, Weber, et al. A systematic review of prevalence studies of depression in Parkinson's disease[J]. Movement Disorders, 2008,23(2): 183-189. 被引量:1
  • 4Nuti A, Ceravolo R, Dell'Agnello G, et al. Environmental factors and ParkinsonTs disease: a case-control study in the Tuscany region of Italy. 2004,11 (5) : 315-320. 被引量:1
  • 5DrevetsWC. Neuroimaging studies of mood disorders[J] Biol Psychiatry, 2000,48 : 813. 被引量:1
  • 6Weisstaub NV, Zhou M, Lira A, et al. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice[J]. Science(S 1095 -9203), 2006,313(5786): 536-540. 被引量:1
  • 7Drevets WC, Thase ME, Moses-Kolko EL, et al. Serotonin- 1A Receptor Imaging in Recurrent Depression: Replication and Literature Review[J].Nucl Med Bio 1(S0969-8051),2007,34(7):865- 877. 被引量:1
  • 8Gotlib IH, Joormann J, Minor KL, et al. HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression[J]. Biol Psychiatry(S1873-2402 ), 2008,63(9): 847-851. 被引量:1
  • 9Remy P, Doder M, Lees A, et al. Depression in ParkinsonTs disease: loss of dopamine and noradrenaline innervation in the limbic system[J]. Brain, 2005,128(6) : 1314-1322. 被引量:1
  • 10Barrero F J, Ampuero I, Morales B, et aJ. Depre ssion in.Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptorgene(CNR 1)[J]. Pharmacogenomics J, 2005,5/2) : 135-141. 被引量:1

引证文献1

二级引证文献5

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈
新型冠状病毒肺炎防控与诊疗专栏