Objective To study the relationship between the insulin resistance and pancreatic β-cell function in gestational diabetes mellitus during different pregnancy periods. Methods Three groups ： normal non-pregnant women （ group Ⅰ ）, normal pregnant women （group Ⅱ ）and gestational diabetes mellitus （GDM） women（groupⅢ ） were all measured for blood glucose and insulin levels by 100g oral glucose tolerance test after fasting, 30min, lh, 2h, 3h. In order to acquire the insulin levels during different stages of pregnancy, blood test were carried out for Group Ⅱ and Group Ⅲ. HOMA-IR and HOMA-β cell function index were used to evaluate insulin excretion function. Results Insulin levels of group Ⅱ and group Ⅲ are of peak distribution and had no significant difference at birth （ P 〉 0. 05）. However, they showed significant difference at other periods of pregnancy（ P 〈0.01 ）. The blood glucose and insulin levels of group m after fasting was significantly higher than those of Group Ⅰ and Group Ⅱ（ P 〈0. 01 ）. The HOMA-IR values for the three groups were 0. 86 ±0. 32, 1.13 ± 0. 26 and 1.75 ± 0. 22 respectively, which were significantly different （ P 〈 0.05）. The values of pancreatic β-cell function index （ HOMA-β） of the groups Ⅱ and Ⅲ were5.20±0.40, 4.36±0.27, which also showed significant difference （ P 〈0.01）. Conclusion Comparing with the group of normal pregnant women, the group m patients have more insulin resistance, which is accompanied by the decrease of the pancreatic β-cell secretion function.
Journal of Chinese Physician
Islets of langerhans