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丹参注射液对COPD患者肺功能、痰生化指标及机体免疫功能的影响 预览 被引量:10

Effect of danshen injection on the pnlmonary function,biochemlcal indices of sputum and immunological function in patients with COPD
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摘要 目的:研究丹参注射液对慢性阻塞性肺疾病(COPD)患者痰生化指标及机体免疫功能的影响。方法:85例COPD缓解期患者分为丹参治疗组(治疗组)47例和对照组38例。两组均进行COPD常规治疗,治疗组除常规治疗外行丹参注射液10ml静脉滴入,每日1次。两组患者均在治疗前及治疗后(3个月)分别检测用力肺活量(FVC)、第一秒用力呼气量(FEV1.0)及1秒用力呼气量与用力肺活量比值(FEV1.0%),检测诱导痰液中IL-6、TNFα血液IgG、IgM、IgA水平KCD3、CD4、CD8阳性细胞率。结果:与对照组比较,治疗组患者治疗后FEV1.0、FEV1.0%升高,痰液IL-6,和TNFα心水平显著下降,血液IgG水平KCD3、CD4、CD4/CD8显著上升。结论:丹参治疗COPD具有减轻气道局部炎症、提高肺通气功能及机体免疫力的作用。 Objective:To study the effect of danshen injection on the pulmonary function,biochemical indices of sputum and immunological function in patients with chronic obstructive pulmonary disease (COPD).Methods:85 patients with COPD were divided into control group (38 patients) and danshen group (47 patients).All the patients with COPD were treated with routine nethod,besides this the danshen qroup was added with danshen injection 10 ml intravenous drip once a day.3 months later,FVC,FEV1.0 and FEV1.0% were detected.The content of IL-3 and TNF-2 in sputum and the content of lgG,lgM,lgA,ratio of CD3,CD8 were detected respectively.Results:FEV1.0 and FEV1.0% of the treatmet group were higher than those of the control group.The content of IL-6 and TNF-2 in sputum decreased and the level of lgG increased.The ratio of CD3,CD4 and CD4/CD8 increased significantly.Conclusiun:Danshen injection can relieve airway local inflammation and rise pulmunay ventilation function and immunity.
作者 邓秀英 代中全 杨向琼 唐丕春 DENG Xiu-ying, DAI Zhong-quan, YANG Xiang-qiong, et al. (Department of Agent, The People's Hospital of Suining, Sichuan 629000,China)
机构地区 遂宁市人民医院
出处 《现代医药卫生》 2007年第4期 486-488,共3页 Modern Medicine Health
关键词 丹参 慢性阻塞性肺疾病 细胞因子 诱导痰 Danshen COPD CeUfactor Induced sputum
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参考文献10

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