Four components from faeces trogopterori (WLZ) extract: WLZ A, B, C,D were isolated for elucidating the protective effect of which on gastric mucosa and identifying the effective principle. Shay model and reserpine model were used. The results showed that the amount of gastric juice, gastric acidity and total secreting acid of WLZ B groups were significantly lower than that of the control group ( P <0.01). The lesion scores of WLZ B groups in both models were significantly lower compared with control groups ( P <0.01). These results indicate that the mechanism by which the WLZ B protect mucosa and prevent ulceration is due to inhibition of the gastric secrection.
Academic Journal of Sun Yat-sen University of Medical Sciences
gastric mucosa/drug effects
stomach ulcer/ zhong yi yao liao fa