期刊文献+

年轻乳腺癌患者的病理学和生物学特征及其与预后的关系 预览 被引量:28

Clinicopathological and biological features of breast cancer in young females and their relationship with prognosis
在线阅读 下载PDF
分享 导出
摘要 目的 分析与年轻乳腺癌患者预后相关的临床、病理学及生物学因素,筛选预后不良因素。方法 回顾性分析≤35岁女性原发性乳腺癌99例,收集临床资料,复习病理切片相关指标,并对其中63例蜡块完整者采用免疫组化方法检测雌激素受体(ER)、孕激素受体(PR)、雄激素受体(AR)、c-erbB2、ki67、p53和BRCA1蛋白表达。结果 99例均随访5年,随访率100%。全组淋巴结转移率为59.6%(59/99),5年远处转移率为28.0%(26/93),5年生存率为72.7%(72/99)。单因素分析显示,淋巴管侵犯、软组织受累、广泛性导管内癌成分(EIC)、淋巴结受累及AR、c-erbB2表达对预后有影响。多因素Cox回归分析表明,淋巴结受累状况、AR和c-erbB2表达是独立预后因素。结论 淋巴结状况和c-erbB2表达是影响年轻乳腺癌患者预后的独立预后因素,AR可作为一种辅助预后因子,人为干预不能从根本上影响患者转归。 Objective To study the relationship between clinicopathological and biological characteristics and prognosis in young females with breast cancer. Methods The clinicopathological data of 99 young patients (≤35years) with primary breast cancer were analyzed retrospectively. All the 99 patients were followed up for 5 years. The histological specimens were reviewed. The expression of ER, PR, AR, c- erbB2, ki67, p53 and BRCA1 were assessed by immunohistochemistry in 63 carcinomas. Results The lymph node involvement, 5-year metastasis and 5-year survival rate were 59.6% (59/99), 28.0% (26/ 93) and 72.7% (72/99), respectively. The univariate analysis showed that the survival was related to lymphatic vessel invasion, fat involvement, node-positive status, EIC, AR and c-erbB2 expression. The COX multivariate analysis identified that only node-positive status, AR negativity and c-erbB2 overexpression were independent prognostic factors. Conclusion Our data demonstrated that the lymph node status and c- erbW2 expression are strong prognostic factors in young patients with breast cancer. AR may be an adjuvant prognostic factor. The therapeutic measurement could not benefit the outcome radically.
作者 孟洁 郎荣刚 范宇 付丽 MENG fie, LANG Rong-gang, FAN Yu, FULi. (Department of Breast Pathology, Tianjin Cancer Hospital, Tianfin Medical University, Tianjin 300060, China)
出处 《中华肿瘤杂志》 CAS 北大核心 2007年第4期 284-288,共5页 Chinese Journal of Oncology
基金 天津医科大学科学基金(2004KY48)
关键词 乳腺肿瘤 预后 病理学 生物学 Breast neoplasms Prognosis
作者简介 通讯作者:付丽,E-mail:fulijyb@hotmail.com
  • 相关文献

参考文献15

  • 1Xiong Q, Valero V, Kau V, et al. Female patients with breast carcinoma age 30 years and younger have a poor prognosis. Cancer, 2001, 92:2523-2528. 被引量:1
  • 2Sidoni A, Cavaliere A, BeUezza G, et al. Breast cancer in young women: clinicopathological features and biological specificity. Breast, 2003, 12:247-250. 被引量:1
  • 3Rapiti E, Fioretta G, Verkooijen HM, et al. Survival of young and oIder breast cancer patients in Geneva from 1990 to 2001. Eur J Cancer, 2005, 41:1446-1452. 被引量:1
  • 4Foo CS, Su D, Chong CK, et al. Breast cancer in young Asian women: study on survival. ANZ J Surg, 2005, 75: 566-572. 被引量:1
  • 5Han W, Kim SW, Park LA, et al. Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer, 2004, 4:82-90. 被引量:1
  • 6Zhou P, Recht A. Young age and outcome for women with earlystage invasive breast carcinoma. Cancer, 2004, 101 : 1264-1274. 被引量:1
  • 7Sundquist M, Thorstenson S, Brudin L, et al. Incidence and prognosis in early onset breast cancer. Breast, 2002, 11:30-35. 被引量:1
  • 8Maggard MA, OconneU JB, Lane KE, et al. Do young breast cancer patients have worse outcomes? J Surg Res, 2003, 113 : 109-113. 被引量:1
  • 9王中华,徐兵河.129例30岁以下女性乳腺癌的临床特点及预后分析[J].中华肿瘤杂志,2005,27(2):111-113. 被引量:39
  • 10Curigliano G, Rigo R, CoUeoni M, et al. Adjuvant therapy for very young women with breast cancer: response according to biologic and endocrine features. Clin Breast Cancer, 2004, 5:125-130. 被引量:1

二级参考文献24

  • 1胡国清,胡长耀.30岁以下女乳腺癌预后因素探讨(附52例临床分析)[J].同济医科大学学报,1994,23(3):244-244. 被引量:1
  • 2Le Doussal V, Tubiana-Hulin M, Friedman S, et al. Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas.Cancer,1989,64:1914-1921. 被引量:1
  • 3Iguchi C, Nio Y, Itakura M. Heterogeneic expression of estrogen receptor between the primary tumor and the corresponding involved lymph nodes in patients with node-positive breast cancer and its implications in patient outcome. J Surg Oncol,2003,83:85-93. 被引量:1
  • 4Chu KC, Anderson WF. Rates for breast cancer characteristics by estrogen and progesterone receptor status in the major racial/ethnic groups. Breast Cancer Res Treat,2002,74:199-211. 被引量:1
  • 5Tsutsui S, Ohno S, Murakami S,et al. Prognostic value of DNA ploidy in 653 Japanese women with node-negative breast cancer.Int J Clin Oncol,2001,6:177-182. 被引量:1
  • 6Faneyte IF, Schrama JG, Peterse JL,et al. Breast cancer response to neoadjuvant chemotherapy: predictive markers and relation with outcome. Br J Cancer,2003,88: 406-412. 被引量:1
  • 7Schmitt FC, Leal C, Lopes C. p53 protein expression and nuclear DNA content in breast intraductal proliferations. J Pathol, 1995,176:233-241. 被引量:1
  • 8Allred DC, Clark GM, Elledge R, et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst,1993,85:200-206. 被引量:1
  • 9Clahsen PC, van de Velde CJ, Duval C, et al. p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer. J Clin Oncol,1998,16:470-479. 被引量:1
  • 10Mansour EG, Ravdin PM, Dressler L. Prognostic factors in early breast carcinoma. Cancer, 1994,74: 381-400. 被引量:1

共引文献50

同被引文献347

引证文献28

二级引证文献128

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈