Objective To investigate the resistance of Staphylococcus aureus to sixteen kinds of antimicrobial agents in the intensive care unit, and to provide basis for clinical therapy. Methods K-B disk diffusion method was used to determine the drug susceptibility of 266 strains of Staphylococcus aureus （SAU）, and methicillin-resistance SAU was detected by using the disk diffusion method according to NCCLS. Results In ICU, SAU was isolated mostly from the respiratory tract, accounting for 74.4%. The isolated rate of MRSA increased from 61.3% in 2001 to 97.4% in 2006. The positive rate of beta lactamase was 100. 0%. No SAU strains resistant to vancomycin and teicoplanin were found. SAU showed high drug resistance to other antibiotics, and the resistant rate of 100.0% to penicillin kept for continuous three years. Conclusion MRSA were the main infection of Staphylococcus aureus in the intensive care unit. Rational use of antibiotics should be carried out according to reporting of drug resistance, and measures should be taken to control the spread of MRSA infection.
International Journal of Laboratory Medicine
Intensive care units Staphylococcus infections
Drug resistance, microbial