To investigate the impact of asphyxia on gastrointestinal tract in newborn infants with birth asphyxia, we measured serum gastrin and plasma motilin concntration via radioimmunoassay in 28 term newborns with birth asphyxia before enteral feedings and on the seventh day after birth, and compared with those of normal controls. The results showed that in newborns with birth asphyxia the level of serum gastrin decreased and the level of plasma motilin increased before enteral feeding after birth in comparison with hose of normal controls (116±7 ng/L vs. 135±4 ng/L, P <0.05 and 431±38ng/L vs. 304±22 ng/L, P <0.01,respectively). The concentrations of both hormones were enhanced on the seventh day (gastrin: 132+8 ng/L, motilin: 726±60 ng/L) in comparison with those obtained immediately after birth ( P <0.05, P <0.01). These results suggest that in neonates with birth asphyxia the change in levels of blood gastrin and motilin may be one of the pathogenic factors of some gastrointestinal symptoms.
Chinese Journal of Pediatrics
Infant, newborn Asphyxia Gastrin Motilin