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荧光猝灭法测定盐酸胺碘酮含量 预览 被引量:1

Determination of amiodarone hydrochloride by fluorescent quenching
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摘要 目的:建立荧光猝灭法测定盐酸胺碘酮片剂含量的新方法。方法:试验多种荧光试剂加入系列浓度的胺碘酮溶液,测定其荧光光谱的变化。结果:选用芘丁酸(PBA)为荧光试剂,浓度为2.0mg·L^-1,λex/λem=349nm/376.3nm,在2.0~20mg·L^-1胺碘酮浓度范围与荧光猝灭值(F0/F)成良好的线性关系(r=0.9962),据此提出测定片剂中胺碘酮含量的荧光猝灭法。结论:荧光猝灭法简便灵敏、选择性高,可用于药片中盐酸胺碘酮含量的测定。 Objective:Investigate fluorescence spectra of amiodarone hydro chloride according to the article;To establish a novel method for the determination of amiodarone by fluorescence quenching. Methods: Fluorescence spectral measurement of amiodarone was carried out according to the method expressed by the article ; after adding series of AD solutions into fluorophore solutions with given concentration, fluorescence intensities were measured, tried several type of fluorophores. Results: 1 - pyrenebutyric acid (PBA) was the best in the experiment, λex/λem = 349 nm/ 376.3 nm, amiodarone concentration in 2. 00 - 20. 0mg·L^-1 was linearly proportional to quenching amount ( F0/ F), r = 0. 9962. Based on this ,a fluorescence quenching method for the determination of amiodarone was proposed. Conclusion: The result of the experiment was different from the result reported in the article ; the proposed method is simple, rapid, sensitive, selective and applicable for the determination of amiodarone in tablet form.
作者 吐尔洪·买买提 陈坚 阿布力克木·阿布力孜 迪丽努尔·塔里甫 Turhum MUHAMMAD,CHEN Jian, Abulikemu ABULIZI, Dilnur TALIP ( 1. College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China; 2. College of Chemistry&Chemical Engineering, Xinjiang University, Urumqi 830046, China)
出处 《药物分析杂志》 CAS CSCD 北大核心 2007年第7期 993-996,共4页 Chinese Journal of Pharmaceutical Analysis
基金 新疆维吾尔自治区高技术研究发展计划资助项目(200311110) 新疆大学青年教师科研启动基金资助项目(QN040109)
关键词 盐酸胺碘酮 荧光探针 含量测定 荧光猝灭 芘丁酸 amiodarone hydrochloride fluorescence probe determination fluorescence quenching 1 - pyrenebutyric acid
作者简介 通讯作者:Tel:(0991)4362246;E-mail:chenjxyd1804@126.com
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