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乙型肝炎e抗原阳性慢性乙型肝炎的遗传易感性与HLA—DRB1等位基因相关性研究 预览

Association between HLA - DRB1 allele polymorphism and the genetic susceptibility to chronic hepatitis B with HBeAg positive
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摘要 目的 探讨河南地区汉族人群乙型肝炎e抗原阳性慢性乙型肝炎遗传易感性与人类白细胞抗原DRB1等位基因多态性的关系。方法 应用聚合酶链反应-序列特异性引物技术,对河南汉族38例乙型肝炎e抗原阳性慢性乙型肝炎患者及42例正常健康人进行了HLA—DRB1^* 1201/1202、^*1501/1502等位基因检测,应用统计学软件SPSS10.0对两组实验结果进行X^2检验。结果 两组的HLA—DRB1^*1201/1202、^*1501/1502等位基因频率差异无统计学意义。结论 HLA—nRR1^*1201/1202、1501/1502等位基因与乙型肝炎e抗原阳性慢性乙型肝炎的形成无相关性。 Objective To study the association of HLA - DRB1 allele polymorphism with the genetic susceptibility to chronic hepatits B (CHB) of HBeAg positive. Methods Thirty - eight patients with CHB of HbeAg positive in Henan were investigated for HLA - DRB1 ^* 1201/1202, ^*1501/1502 alleles by polymerase chain reaction - sequence specific primers( PCR - SSP) technique. The results were compared with those from 42 normal healthy people by use of X^2 - test of Microsoft SPSS 10.0. Results The frequencies of HLA - DRB1^* 1201/1202, *^1501/1502 alleles in patient group were not significantly different compared with the frequencies in control group. Conclusion HLA - DRB1 ^*1201/1202, ^*1502/1502 alleles have no association with CHB of HbeAg positive patients in Henan Han nationality.
作者 段东杰 祐红瑞 范会兴 江河清 DUAN Dongjie, YOU Hongrui ,FAN Huixing ,JIANG Heqing( Department of Internal Medicine ,the First People's Hospital of Ruzhou,Ruzhou 467500,Henan; 2. Department of Infectious Disease ,the First Affiliated Hospital of Zhengzhou University )
出处 《中原医刊》 2007年第15期 13-14,共2页 Central Plains Medical Journal
关键词 人类白细胞抗原DRB1等位基因 乙型肝炎e抗原阳性 慢性乙型肝炎 遗传易感性 Hunman leukecyte antigen DRB1 allele HBeAg positive Chronic hepatitis B Genetic susceptibility Yolymerase chain reaction- sequence specific primers
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