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牛肌生成抑制素功能基因的克隆与原核表达 预览

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摘要 Mcpherron等在研究转化生长因子-β(TGF-β)超家族时,用该家族的蛋白质同源保守序列设计引物,以小鼠基因组DNA为模板,应用PCR扩增得到一种新的生长因子,命名为生长分化因子-8(GDF-8)。GDF-8基因突变的牛为双肌牛,MSTN基因发生突变,会引起肌肉过度发育,肌纤维数增加或肌纤维直径变大、皮下脂肪减少。肌生成抑制素(Myo-statin,MSTN)是生长转化因子TGF-β超家族的成员,是骨骼肌生长发育的负调控因子,所以肌生成抑制素的研究对于提高动物生产性能有重要意义。
出处 《黑龙江畜牧兽医》 CAS 北大核心 2007年第9期 28-30,共3页 Heilongjiang Animal Science And veterinary Medicine
基金 黑龙江省教育厅科学技术项目(10551225)
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参考文献4

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二级参考文献20

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