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参附芎泽注射液对压力超负荷大鼠血液流动力学和心肌组织及血清TNF-αIL-1βIL-6含量的影响 预览 被引量:2

ShenFu XiongZe Injection:Its Effects on Hemodynamics and Myocardium and the levels of TNF-α、IL-1β、IL-6 in Experimental Pressure - Overloaded Rats
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摘要 目的:参附芎泽注射液对压力超负荷大鼠血流动力学和心肌组织及血清TNF—α、IL-1β、IL-6含量的影响。方法:参照Ohkusa等介绍的方法复制腹主动脉缩窄大鼠模型。48只SD大鼠随机分为假手术组(12)和造模组(36),术后4周将造模组随机分为模型组(11)、参附芎泽注射液治疗组(11)和依那普利治疗对照组(11)。参附芎泽注射液8mL/(kg·d),依那普利对照组剂量为10mg/(kg-d),假手术组和模型组腹腔注射等剂量生理盐水,干预时间共28天。术后8周,测定血流动学指标后处死动物,用ELASA法测定压力超负荷大鼠血清TNF-α、IL-1β、IL-6含量;用EIASA法测定心肌组织TNF-α、IL-1β、IL-6含量。结果:与假手术组相比,模型组左室内压力峰值(LVSP)、左心室内压最大下降速率(-LVdp/dtmax)及左心室内压最大上升速率(+LVdp/dtmax)下降;收缩压(SBP)、舒张压(DBP)、左室舒末期压(LVEDP)均升高;模型组心肌组织及血清TNF-α、IL-1β、IL-6含量均明显高于假手术组(P〈0.01)。参附芎泽注射液各项指标均低于模型组(P〈0.05和P〈0.01),能降低心肌组织及血清TNF-α、IL-1β、IL-6含量,与依那普利组比较无显著性差异(P〉0.05)。结论:参附芎泽注射液可改善压力超负荷心衰大鼠血流动力学指标,降低心肌组及血清TNF-α、IL-1β、IL-6含量,阻断这些细胞因子对心肌重塑的影响。 Objective :To investigate the effects ofShenFu XiongZe Injection upon the hemodynamics and the levels of TNF-α,IL-1β,IL-6 in the experimental pressure- overloaded rats. Methods :Creating a condition of aorta ventralis coarctation in experimental rats in the way Ohkusa reported. Of the 48 experimental rats, 12 are classified randomly to a sham - operation group and 36 to a would - be group, both of which are injected abdominally equal amount physiologic saline and are interfered for 28 day. 4 weeks after the operation,the would - be group are further classified randomly to an Injection - treated group( 11 ) in which SheFu QiongZe Injection is applied by 8mL/kg,a model group( 11 ) and a control group treated by 10mL/kg of Enalapril. With the hemodynamics being measured and the popluar being kiUed 8 weeks later,the levels of TNF-α,IL-1β,IL-6 are measured by RIA method. Results :Comparing with the sham - operation group, in the model group, the LVSP, - LVdp/dtmax and + LVdp/dtmax are lowered, and SBP, DBP, LVEDP are raised. The levels of TNF-α,IL-1β,IL-6 in the would -be group are notably higher than the sham- operation group( P 〈 0.01 ). In the treated group, all indices are lower than the model group( P 〈 0.05 )and ( P 〈 0.01 ), indicating that ShenFu QiongZe Injection could decrease the levels of TNF-α,IL-1βSand IL- 6 ,but there is no significant difference comparing with the Enalapril group ( P 〈 0. 05 ). Conclusion : ShenFu QiongZe Injection can have an effect on the hemodynamics of the heart failure in the pressure - overloaded rats, that is, the levels of TNF-α,IL-1β and IL- 6 are lowered to stop the negative actions from these cytokines.
作者 于远望 韩曼 张淑珍 黄文华 赵晓明 宋亮 YU Yuan-wang,HAN Man ,ZHANG Shu-zhen ,HUANG Wen-hua ,ZHAO Xiao-ming,SONG Liang ( Shaanxi University of Tradicional Chinese Medicine, Xianyang 712046, Shaanxi, China)
机构地区 陕西中医学院
出处 《辽宁中医杂志》 CAS 北大核心 2008年第8期 1266-1268,共3页 Liaoning Journal of Traditional Chinese Medicine
基金 陕西省中医药管理局资助项目(2005051) 陕西省教育厅资助项目(2006JK312)
关键词 参附芎泽注射液 压力超负荷大鼠 心肌组织 血清 TNF-α、IL-1β、IL-6 ShenFu XiongZe Injection Experimental Pressure - Overloaded Rats myocardium blood serum TNF-α,IL-1β,IL-6
作者简介 于远望(1965-),男,陕西兴平人,副教授,学士,主要从事心血管生理学研究。
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