期刊文献+

Cyclin D1和Ki67与涎腺黏液表皮样癌发生及预后的相关性研究 被引量:6

Relationship between Expression of Cyclin D1 and Ki 67 and Salivary Gland Mucoepidermoid Carcinoma Develop- ment and Prognosis
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摘要 目的:检测Cyclin D1和Ki67在黏液表皮样癌MEC(Mucoepidermoid Carcinoma,MEC)中的表达状况,探讨其与MEC发生及预后的相关性。方法:采用免疫组织化学染色方法,分别检测CyclinD1和Ki67在10例正常涎腺组织(normalsalivary gland,NSG)及34例MEC组织中的表达情况。实验数据采用SPSS11.5软件进行统计学分析。结果:CyclinD1和Ki67在NSG中基本无表达,而在MEC中阳性表达率明显增高,且低分化组高于高分化组,复发组和转移组比无复发组和无转移组阳性表达率显著增高,但与患者性别、年龄及发生部位无相关性。结论:CyclinD1在MEC中高表达,提示其表达异常是MEC发生的重要机制之一;CyclinD1和Ki67与MEC的分化程度显著相关,因此可以作为评价MEC分化程度的生物学标志物;其过度表达与MEC的复发转移显著相关,故联合检测Cyc1inD1和Ki67将有助于预测肿瘤患者的预后。 Objectives: To investigate the expression of Cyclin D1 and Ki67 in MEC and assess their roles in the carci- nogenesis and prognosis of MEC. Methods: The immunohistochemical method was used to detect the expression of Cyclin D1 and Ki67 in 34 cases of MEC and 10 cases of noinml salivary glands (NSG). Data were analyzed using SPSS version 11.5 for windows. Results : Cyclin D1 and Ki67 expression could hardly be observed in normal salivary glands, but in MEC showed positive staining. There was a significant difference between the high grade and the low grade of MEC. Moreo- ver, Cyclin D1 and Ki67 positive expression could be recognized in all recurrent and metastasis cases. There were no obvious correlations between the expression and sex or age. Conclusion : The expression of Cyclin D1 might play a certain role in the development and progression of MEC. Cyclin D1 and Ki67 expression also related with the recurrence and metastasis of MEC. Combined analysis of the expression of Cyclin D1 and Ki67 might be useful to make the diagnosis and prognosis of MEC.
作者 许宁 朱恩新 刘婷姣 XU Ning, ZHU En - xin, LIU Ting - jiao. (Stomatology College, Dalian Medical University, Dalian 116044)
出处 《口腔医学研究》 CAS 2008年第6期 625-628,共4页 Journal of Oral Science Research
基金 国家自然科学基金资助课题(编号:30700955)大连市优秀青年科技人才基金资助课题(编号:1(2008J23.1H037)
关键词 涎腺 黏液表皮样癌 CYCLIN D1 KI67 Salivary gland Mucoepidermoid Carcinoma Cyclin D1 Ki67
作者简介 许宁(1978-),女,江苏无锡人,医师,硕士,主要从事口腔病理和口腔临床工作。 通讯作者 朱恩新,电话:(0411)86110400
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参考文献10

  • 1于世凤主编..口腔组织病理学[M],2007:390.
  • 2蔡传宝,陶学金,朱声荣,陈卫民,汤国雄,向国林.TGF-β1、Smad4和CyclinD1在口腔鳞癌中的表达和意义[J].口腔医学研究,2007,23(1):14-16. 被引量:8
  • 3Shiratsuchi ,H, Nakashima T, Hirakawa N et al. beta-Catenin nuclear accumulation in head and neck mucoepidennoid carcinoma: its role in cyclin D1 overexpression and tumor progression[J].Head Neck,2007, 29(6): 577 -584 被引量:1
  • 4Miguel MC, Oliveira MC, Seabra FRet al. Beta - catenin and cyclin D1 in mucoepidermoid carcinoma of variable histologic grades [J]. Arch Otolaryngol Head Neck Surg,2005,131 (8): 701 - 706 被引量:1
  • 5李松英,边国新,胡济安.黏液表皮样癌中β-连环素和细胞周期蛋白D1表达的相关性研究[J].口腔医学,2006,26(3):179-181. 被引量:2
  • 6Murakami M, Ohtani I, Hojo H, et al. hmnunohistochemical evaluation with Ki67: an application to salivary gland tumours [J]. Laryngol Otol, 1992, 106(1):35 -38 被引量:1
  • 7Zhu Q, Tipoe GL, White FH. Proliferative activity as detected by immunostaining with Ki67 and proliferaling cell nuclear antigen in benign and malignant epithelial lesiSns of the human parotid gland [ J]. Anal Quant Cytol Histol, 1999, 21 (4) : 336 被引量:1
  • 8Lazzaro B, Cleveland D. P53 and Ki67 antigen expression in small oral biopsy specimens of salivary gland tumors [ J ]. Oral Surg Oral M ed Oral PatholOral Radiol Endod, 2000, 89 (5) : 613 被引量:1
  • 9Kiyoshima T, Shima K, Kobayashi I, et al. Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands [J]. Oral Oncol, 2001, 37 (3): 315 - 322 被引量:1
  • 10Skalova A, Lehtonen H, von Boguslawsky K, et al. Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland : clinicopatholo - gic study using MIBI antibody in paraffin sections[J].Hum Pathol, 1994, 25:929 被引量:1

二级参考文献15

  • 1Behrens J,Lustig B.The Wnt connection to tumorigenesis[J].Int J Dev Biol,2004,48(5-6):477-487. 被引量:1
  • 2Maruyama K,Ochiai A,Akimoto S,et al.Cytoplasmic betacatenin accumulation as a predictor of hematogenous metastasis in human colorectal eancer[J].Oncology,2000,59(4):302-329. 被引量:1
  • 3Luu HH,Zhang R,Haydon RC.et al.Wnt/beta-catenin signaling pathway as a novel cancer drug target[J].Curr Cancer Drug Targets,2004,4(8):653-671. 被引量:1
  • 4Liu H,Rdisky DC,Wang F,et al.Polarity and proliferation are controlled by distinct signaling pathways downstream of P13-kinase in hreast epithelial tumor cells[J].J Cell Biol,2004,164(4):603-612. 被引量:1
  • 5Nelson WJ,Nusse R,Convergence of Wnt,β-catenin,and cdherin pathways[J].Science,2004,303(5663):1483-1487. 被引量:1
  • 6Wang C,Li Z,Fu M,et al.Signal transduction mediated by cyclin D1:from mitogens to cell proliferation:a molecular target with therapeutic potential[J].Cancer Treat Res,2004,119:217-237. 被引量:1
  • 7Semezuk A,Jakowicki JA,Alterations of pRbl-cyclin D1-cdk4/6-p16(1NK4A)pathway in endometrial carcinogenesis[J].Cancer Lett,2004,203(1):1-12. 被引量:1
  • 8Fu M,Wang C,Li Z,et al.Cyelin D1:Normal and abnormal functions[J].Endoerinology,2004,145(12):5439-5447. 被引量:1
  • 9Rowlands TM,Pechenkina IV,Hatsell S,et al.Beta-catenin and cyclin D1:connection development to breast cancer[J].Cell Cycle,2004,3(2):145-148. 被引量:1
  • 10Park BJ,Park JI,Byun DS,et al.Mitogenic conversion of trans-forming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer[J].Cancer Res,2000,60(11):3 031-3 038 被引量:1

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