期刊文献+

白藜芦醇结构修饰及药理活性 被引量:3

Structure Modification of Resveratrol and Pharmacological Activity
分享 导出
摘要 从自然界中寻找活性先导化合物,再进行结构修饰,以提高化合物的活性和降低毒性是目前创新药物的一条重要思路。白藜芦醇是在葡萄等植物中广泛存在的植物抗毒素,对人类目前的疾病如肿瘤、心血管疾病、神经退行性疾病和病毒感染等具有良好的预防作用,是一种具有开发潜力的先导化合物。近年来越来越多的科学家对其进行结构改造以得到高活性化合物,例如对双键、苯环的修饰。本文就目前对白藜芦醇修饰及其药理活性进行阐述和讨论。 In order to improve existed in the nature and modifying phytoalexin isolated from grapes and activity and decrease toxicity, searching for lead compounds with biological activity their structures is an important means of innovation of new drugs. Resveratrol, a other plants, is well-known for its potent chemopreventive properties towards the most severe contemporary human diseases, such as cancer, vascular disease, neurodegenerative disease and viral infection, etc. In recent years, more and more scientists modify the double bond or benzene ring of resveratrol to get higher activity, lower toxicity derivates. In this paper, the structure-activity relationships and pharmacological properties of the resveratrol derivatives as a potent chemopreventive agent are reviewed and discussed.
作者 刘华臣 董爱君 高春梅 蒋宇扬 Liu Huachen Dong Aijun Gao Chunmei Jiang Yuyang (1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China; 2. The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; 3. Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China)
出处 《化学进展》 SCIE CAS CSCD 北大核心 2009年第7期1500-1506,共7页 Progress in Chemistry
关键词 白藜芦醇 药理活性 构效关系 resveratrol pharmacological activity structure-activity relationships
作者简介 Corresponding author e-marl : jiangyy @ sz. tsinghua, edu. cn
  • 相关文献

参考文献93

  • 1Sanders T H, McMichael R W, Hendfix K W, et al. J. Agric. Food Chem., 2000, 48:1243-1246. 被引量:1
  • 2Lyons M M, Yu C, Toma R B, et al. J. Agile. Food Chem., 2003, 51:5867-5870. 被引量:1
  • 3Ibem M, Roig-Perez S, Lamuela R M, et al. J. Agric. Food Chem., 2000, 48:6352-6354. 被引量:1
  • 4Gerogiannaki C M, Athanasopoulos P, Kyriakidis N, et al. Food Control, 2006, 17:700-706. 被引量:1
  • 5Counet C, Callemien D, Collin S. Food Chem., 2006, 98: 649- 657. 被引量:1
  • 6Bavareseo L, Vezzulli S, Civardi S, et al. J. Agric. Food Chem., 2008, 56:2085-2089. 被引量:1
  • 7Sobolev V S. J. Agrie. Food Chem., 2008, 56:1949-1954. 被引量:1
  • 8Zhang Y, Li S Z, Li J, et al. J. Am. Chem. Sot., 2006, 128: 13030- 13031. 被引量:1
  • 9Howitz K T, Bitterman K J, Cohen H Y, et al. Nature, 2003, 425 : 191-196. 被引量:1
  • 10Ener G S, Toklu H Z, Ehirli A O, et al. Hepatol. Res., 2006, 35: 62-68. 被引量:1

二级参考文献55

共引文献31

同被引文献41

引证文献3

二级引证文献11

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈