期刊文献+

帕金森病抑郁状态的相关因素研究 预览 被引量:1

Study on correlated factors in patients with Parkinson diseases
在线阅读 免费下载
收藏 分享 导出
摘要 目的研究帕金森病(Parkinson disease,PD)患者抑郁症状的发生率及其相关影响因素。方法2007年3月至2008年3月河南省人民医院神经内科门诊诊断为PD的患者121例,采用抑郁自评量表(self—rating depression scale,SDS)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)对患者进行评定及诊断,统计分析抑郁的发生情况和严重程度及相关影响因素。结果PD患者抑郁的发生率为43.8%(53/121),轻度抑郁占90.6%(48/53);经济状况差、病程长、Hoehn&Yahr分级(简称H—Y分级)高者易出现抑郁;logistic回归分析表明病程和H—Y分级是抑郁的危险因素(OR=11.31,P=0.001,95%CI=3.46~28.69;OR=7.52,P=0.001.95%CI=2.68~18.71)。结论PD患者有较高的抑郁发生率,与PD病程、病情分期密切相关。 Objective To assess the incidence of depression and correlated factors in Parkinson disease. Methods One hundred and twenty-one patients were selected from the department in March 2007 to March 2008. The patients were evaluated with Self-rating Depression Scale(SDS) and Hamilton Depression Scale(HAMD), the disease severity and correlated factors of depression were analyzed. Results The incidence of depression in Parkinson disease patients was 43.8%(53/121) ,of which 90.6%(48/53) was mild depression. Univariate analysis revealed that a high frequency of depression occurred in the patients with bad economic status, long Parkinson disease duration and high Hoehn Yahr stage. The Parkinson disease duration and Hoehn & Yahr stage association achieved significance when multivariable logistic regression analysis was used for the risks of Parkinson disease depression ( OR = 11.31, P = 0.001,95% CI =3.46-28.69; OR =7.52, P =0.001,95% CI =2.68-18.71). Conclusion Parkinson disease patients have a high susceptibility to depression,and duration of PD and Hoehn & Yahr stage appear to be the strongest predictor of depression.
作者 王冰 徐军 李学 WANG Bing,XU Jun,LI Xue (Department of Neurology, People's Hospital of Henan Province,Zhengzhou 450003,China)
出处 《临床荟萃》 CAS 2009年第20期1775-1777,共3页 Clinical Focus
关键词 帕金森病 抑郁 诊断 Parkinson disease depression diagnosis
  • 相关文献

参考文献8

二级参考文献35

  • 1苏亮,施慎逊,肖世富,刘福根,李冠军,王志阳,张明园.老年抑郁症和焦虑障碍共病患者的临床特征[J].中国心理卫生杂志,2006,20(3):166-169. 被引量:36
  • 2蔡晓杰,陈海波,王新德,贡慧华.帕金森病患者的智能障碍——瑞文测验的应用及意义[J].脑与神经疾病杂志,1997,5(2):94-96. 被引量:12
  • 3卫生部药政局.新药(西药)临床研究指导原则汇编[M].北京,1993.48-49. 被引量:8
  • 4王新德.帕金森病及帕金森综合征的诊断标准和鉴别诊断[J].中华神经精神科杂志,1985,18(4):256-256. 被引量:127
  • 5胡昌恒 袁光固 等.帕金森病的神经心理学研究[J].中华神经精神科杂志,1985,18:219-219. 被引量:17
  • 6王新德.帕金森病及帕金森综合征诊断标准和鉴别诊断[J].中华神经精神科杂志,1986,18(4):255-255. 被引量:2
  • 7王拥军.卒中单元[M].北京:科学技术文献出版社,2003.. 被引量:86
  • 8YAMAMOTO M.Depression in Parkinson's disease: its prevalence,diagnosis,and neurochemical background[J].J Neurol,2001,248(suppl 3):5-11. 被引量:1
  • 9ALLAIN H,SCHUCK S,MAUUIT N.Depression in Parkinson's disease[J].Br Med J,2000,320(7245):1287-1288. 被引量:1
  • 10MENZA M A,MARK M H.Parkinson's disease and depression: the relationship to disability and personality[J].J Neuropsychiatry Clin Neurosci,1994,6(2):165-169. 被引量:1

共引文献32

同被引文献6

  • 1张振馨,.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409. 被引量:539
  • 2Zhang ZX,Roman GC, Hong Z, et al. Parkinsons disease in China:prevalenee in Beijing, Xian and Shanghai[J]. Lancet, 2005,365 (9459) :595-597. 被引量:1
  • 3Stamey W, Davidson A, Jankovic J. Shoulder pain: a presenting symptom of Parkinson disease[J]. J Clin Rheumatol, 2008, 14 (4) :253-254. 被引量:1
  • 4Marek K,Jennings D. Can we image premotor Parkinson disease [J]. Neurology, 2009,72 ( 7Suppl),S21-S26. 被引量:1
  • 5Hattingen E, Magerkurth J, Pilatus U, et al. Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinsons disease[J]. Brain,2009,132(Pt 12) :3285-3297. 被引量:1
  • 6Tokuda T,Qureshi MM, Ardah MT,et al. Detection of elevated levels of a-synuelein oligomers in CSF from patients with Parkinson disease[J]. Neurology, 2010,75(20) : 1766-1772. 被引量:1

引证文献1

二级引证文献2

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈