The fact that treatment of leukemia (Acute Promyelocytic Leukemia ) with ATRA ( All-Trans Retinoic Acid) was so succeeded that it was considered as a good example for tumor therapy. In the treatment of solid tumors by means of induced differentiation, however, has not been yet so broken-through. DMSO ( Dimethyl-sulfoxide ) was a common and simple organic compound, which comprised a varity of biological activities. For example, DMSO induced differentiation of leukemia in many reports. However, the effect of DMSO on solid tumors was to be explored further. In the present study, DMSO was
used to human esophageal cancer cell lines in vitro in comparision with the classical inducer A-TRA. From the view of morphology, cell cycle, growth inhibition, cytokeratin 4 expression, dye transfer and tumorigenecity, the results demonstrated that DMSO as well as ATRA could induce differentiation of human esophageal cancer cells. Interestingly, DMSO was comfirmed to be more effective in inducing differentiation of esophageal cancer cells than ATRA. It suggests that DMSO showed some good prospects for the treatment of solid tumors.
Acta Biologiae Experimentalis Sinica
Induced differentiation. Esophageal cancer. Dimethylsulfoxide. Retinoic acid.Tumor therapy