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杂色曲霉产生的新生物活性物质——SIPI—1—2,3和4的研究 预览

Studies on the new bioactive compounds from Aspergillus versicolor SIPI 17 SIPI 1 2,3 and 4
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摘要 目的 筛选和分离微生物产生的胆固醇生物合成酶抑制剂。方法 应用体外酶反应系统筛选具有抑制胆固醇生物合成活性的阳性菌株,通过发酵,溶媒萃取,硅胶柱分离和纯化是活性化合物的单体;测定理化性质和MS,IR,UV,NMR等图谱,确定化合物的化学结构,结果:从杂色曲霉菌株中分离出3个结构类似的醌类化合物,确定其化学结构和总结其生物活性,结论:化合物SIPI-1-3和4为首次报道的新结构化合物,抑制胆固醇生物 OBJECTIVE: To screen and isolate the cholesterol biosynthetic enzyme inhibitors from SIPI 17. METHODS: Using cholesterol biosynthetic enzyme system in vitro , we screened the metabolites of microorganisms and found the strains with immunosuppressant activity; then the pure active compounds were obtained by fermentation, solvent extraction,silica gel chromatography,respectively;the chemical structures were finally elucidated through analyses of physico-chemical properties, MS,IR,UV,NMR spectra,respectively.RESULTS: Three compounds were isolated from Aspergillus versicolor sp. SIPI 17 and their structures were elucidated. CONLUSION:Compound SIPI 1 3 and 4 were first reported with new structures, Their lowering cholesterol biosynthesis activities were first found so far.
作者 胡海峰 朱宝泉 Hu Haifeng(Hu HF),Zhu Baoquan (Zhu BQ),Gong Bingyong (Gong BY) (Shanghai Institute of Pharmaceutical Industry,Shanghai200040)
出处 《中国药学杂志》 EI CAS CSCD 北大核心 1999年第5期 337-339,共3页 Chinese Pharmaceutical Journal
关键词 胆固醇 酶抑制剂 图谱分析 杂色曲霉 cholesterol,enzyme inhibitor,spectrum analysis,Aspergillus versicolor
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