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SDF-1/CXCR4/CXCR7与白血病的研究进展 被引量:2

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摘要 基质细胞衍生因子(stromal cell derivedfactor1,SDF-1)也称为CXCL12(C,X.C chemokine ligand12)是一类具有趋化活性的细胞因子,能调控多种生物学过程包括心脏与神经发育、干细胞运动、血管形成及肿瘤发生。历来认为趋化因子CXCL12与其唯一的特异性受体CXCR4结合所形成的CXCL12/CXCR4生物学轴在多种肿瘤的生长、侵袭、转移中都发挥着重要作用,但Bums JM等研究发现CXCL12尚存在CXCR7这一新受体,并认为CXCR7对肿瘤进程也有潜在作用。
出处 《中华全科医学》 2012年第3期 448-449,共2页 Applied Journal Of General Practice
作者简介 通讯作者:吴广胜,电子信箱:hematology@126.com
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