期刊文献+

阴沟肠杆菌的临床分布及耐药性分析 被引量:10

Clinical distribution and drug resistance of Enterobacter cloacae
收藏 分享 导出
摘要 目的了解医院感染阴沟肠杆菌的临床分布及耐药性,为临床医师合理用药提供依据。方法回顾性分析医院2010年1月-2011年3月临床分离的154株阴沟肠杆菌的感染现状及耐药性。结果阴沟肠杆菌主要。分布于糖尿科、肿瘤科及ICU,分别占50.00%、15.58%、12.99%;在各类标本中的构成比以创面分泌物、痰液较高,分别占64.29%、16.23%;阴沟肠杆菌对亚胺培南耐药率最低为0,对头孢吡肟、左氧氟沙星、阿米卡星耐药率相对较低,分别为25.32%、31.82%、36.36%;对氨苄西林、头孢唑林、氯霉素耐药率相对较高,分别为96.10%、92.21%、78.57%;阴沟肠杆菌产AmpC酶阳性率为46.10%。结论阴沟肠杆菌多药耐药现象较为严重,应加强耐药性监测指导临床医师合理使用抗菌药物。 OBJECTIVE To investigate the clinical distribution and drug resistance of Enterobacter cloacae causing nosocomial infections and provide basis for the clinical application of the antibiotics. METHODS The infection status and drug resistance of 154 E. cloacae from Jan. 2010 to Mar. 2011were retrospectively analyzed. RESULTS E. cloacae isolates were mainly isolated from the department of diabetics (50. 00M), department of tumor ( 15.58 % ), and ICU ( 12.99 % ). Among various specimens collected, the wound secretions and sputum accounted for 64. 290/00 and 16.23% respectively. E. cloacae has the lowest drug resistance rate to imipenem which was 0, and has relatively low resistance rates to cefepime, levofloxacin, and amikacin, which were 25.32%, 31. 820/00 and 36.36 %, respectively; the resistance rates of E. cloacae to ampicillin, cephazolin, and minocycline were relatively high, which were 96.10%, 92.21% and 78.57%, respectively. The positive rate of AmpC-producing E. cloacae was 46. 10%. CONCLUSION Multidrug-resistance of E. cloacae is serious, it is necessary to strengthen the surveillance for drug resistance in order to guide the reasonable use of antibiotics.
作者 吕春兰 李沛 郝爱军 LU Chun-lan, LI Pei, HAO Ai-jun (Xiangyang Traditional Chinese Medical Hospital, Xiangyang, Hubei 441000, China)
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2012年第7期 1494-1496,共3页 Chinese Journal of Nosocomiology
关键词 阴沟肠杆菌 临床分布 耐药分析 Enterobacter cloacae Clinical distribution Drug resistance
  • 相关文献

参考文献6

二级参考文献49

共引文献67

同被引文献79

  • 1戴春梅,周建党,陈辉.医院感染阴沟肠杆菌的耐药性及基因型分析[J].微生物学杂志,2006,26(4):95-98. 被引量:5
  • 2李苏英.一起由阴沟肠杆菌引起食物中毒的实验室检测[J].现代预防医学,2007,34(18):3507-3507. 被引量:12
  • 3周青雪,程东庆.阴沟肠杆菌产口内酰胺酶的研究进展[J].中国抗菌药物杂志,2011,36(12):881-884. 被引量:1
  • 4杜蓉,冯萍,陈慧莉,等.三维试验的改良及对鲍曼不动杆菌的产酶现状和耐药性分析[J].中国抗菌药物杂志,2009,34(5):309-312. 被引量:1
  • 5Jacoby GA. AmpC beta lactamases[J]. Clin Microbiol Rev, 2009, 22(1) =161-182. 被引量:1
  • 6Paterson DL. Resistance in gram negative bacteria: Enterobacteri- aceae[J]. Am J Med,2006,119(6 Suppl 1):$20-28. 被引量:1
  • 7Mezzatesta ML,Gona F,Stefani S. Enterobacter cloacae complex:clinical impact and emerging antibiotic resistance[J]. Future Mi- crobiol, 2012,7 (7) : 887-902. 被引量:1
  • 8Stock I,Griiger T, Wiedemann B. Natural antibiotic susceptibility of strains of the Enterobacter cloacae complex[J]. Int J Antimi- crob Agents,2001,18(6) :537 545. 被引量:1
  • 9Zhou Z,Li L,Yu Y,et al. The status of drug resistance and ampC gene expression in Enterobacter cloacae[J]. Chin Med J (Engl), 2003,116(8) : 1244-1247. 被引量:1
  • 10中华医学会.抗菌药物敏感性试验执行标准[J].第二十三版资料增刊.中华检验医学杂志,2013,33(1):21-23. 被引量:1

引证文献10

二级引证文献45

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈