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帕金森病伴发焦虑与运动症状及非运动症状关系的研究 预览 被引量:14

Investigation on the relationship between anxiety and the motor symptoms or non-motor symptoms in patients with Parkinson's disease
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摘要 目的探讨帕金森病(PD)患者伴发焦虑与运动症状及非运动症状(NMS)的关系。方法对124例PD患者应用汉密尔顿焦虑量表(HAMA)进行评测,分为焦虑组和非焦虑组,并完成相关运动症状及NMS量表评测。结果(1)124例PD患者焦虑发生率为33.87%,焦虑和抑郁共病率为31.45%;(2)两组患者运动症状及运动并发症相关量表评测结果分别为:Hoehn-Yahr分期:2.48±0.80vs.2.04±0.78;UPDRS-Ⅲ(运动):30.68±9.91vs.24.70±12.25;“开-关”现象发生率:35.71%vs.17.07%,两组间具有统计学差异(P〈0.05);两组患者异动症发生率及剂末现象的发生率分别为:14.29%vs.7.32%、45.24%vs.30.49%,两组问无统计学差异(P〉0.05);(3)焦虑组患者出现NMS个数为(14.57±3.83)个,非焦虑组患者为(10.03±5.25)个,两组间均有统计学差异(P〈0.05);(4)焦虑组抑郁、性生活障碍、不宁腿综合征、淡漠、白天思睡、入睡困难、眩晕、疼痛、噩梦以及体位性头晕等NMS发生率高于非焦虑组,两组均有统计学差异(P〈0.05);(5)焦虑组和非焦虑组患者NMS相关量表评测结果分别为:UPDRS-Ⅰ(精神、行为和情绪):4.74±1.93vs.2.93±1.84;HAMD:19.41±6.97vs.9.82±5.83;PSQI:19.48±6.36vs.12.37±6.47:ESS:6.69±5.62vs.3.56±3.34;SCOPA-AUT:43.48±7.75vs.36.76±7.33;RLSRS:21.77±6.51vs.17.29±7.27,两组间具有统计学差异(P〈0.05),两组患者的MMSE、MoCA及Fs-14评分分别为:26.12±4.37vs.27.16±3.28、21.05±6.38vs.22.71±4.67及10.71±2.69vs.9.42±3.26,均无统计学差异(P〉0.05);(6)焦虑组和非焦虑组患者UPDRS-Ⅱ(日常生活活动)以及PDQL评分结果分别为:15.29±5.85vs.12.22±5.39、128.62±20.51vs.149.30±20.13 Objective To explore the relationships between anxiety and the motor symptoms or non-motor symptoms(NMS)in patients with Parkinson's disease(PD).Methods 124 PD patients were collected and divided into anxiety group and non-anxiety group according to the scores of Hamilton Anxiety Scale(HAMA)and a comparison study was conducted by using related motor symptoms and NMS scales.Results(1)33.87% of PD patients were accompanied by anxiety,31.45% of PD patients suffered from anxiety and depression synchronously.(2)Results of motor symptoms and movement complications in the two groups were as followed:Hoehn-Yahr Staging:2.48±0.80 vs.2.04±0.78,UPDRS-Ⅲ(motor):30.68±9.91 vs.24.70±12.25,incidence of"on-off"phenomenon:35.71% vs.17.07%,and there were significant differences between the two groups(P0.05);the incidences of dyskinesia and wearing-off were 14.29% vs.7.32% and 45.24% vs.30.49%,respectively,which were not statistically significant(P0.05).(3)The number of NMS in anxiety group was 14.57±3.83,non-anxiety group was 10.03±5.25,and there was a significant difference between the two groups(P0.05).(4)The incidences of depression,sexual dysfunction,restless legs syndrome,apathy,daytime somnolence,insomnia,dizziness,pain,nightmare and positional vertigo in anxiety group were higer than that in non-anxiety group,and there were significant differences between the two groups(P0.05).(5)Results of NMS in anxiety group and non-anxiety group were as followed:UPDRS-Ⅰ(psychiatrics,cognition and emotion):4.74±1.93 vs.2.93±1.84;HAMD:19.41±6.97 vs.9.82±5.83;PSQI:19.48±6.36 vs.12.37±6.47;ESS:6.69±5.62 vs.3.56±3.34;SCOPA-AUT:43.48±7.75 vs.36.76±7.33;RLSRS:21.77±6.51 vs.17.29±7.27,and there were significant differences between the two groups(P0.05).The scores of MMSE,MoCA and FS-14 in two groups were:26.12±4.37 vs.27.16±3.28,21.05±6.38 vs.22.71±4.67 and 10.71±2.69 vs.9.42±3.26,respectively,and there were no significant differ
作者 刘卓 孙莉 黄曦妍 曹辰杰 余舒扬 左丽君 杨雅琴 朴英善 张巍 LIU Zhuo,SUN Li,HUANG Xi-yan,CAO Chen-jie,YU Shu-yang,ZUO Li-jun,YANG Ya-qin,PIAO Ying-shan,ZHANG Wei.Department of Neurology,Beijing Tiantan Hospital Affiliated to The Capital Medical University,Beijing 100050,China
出处 《中华临床医师杂志(电子版)》 2012年第2期 12-17,共6页 Chinese Journal of Clinicians(Electronic Version)
基金 国家重点基础研究发展计划资助项目(2011CB504100) 国家自然科学基金(81071015) 北京市卫生系统高层次卫生技术人才培养计划资助项目(2009-3-26) 首都医科大学基础-临床科研合作基金(10JL49)
关键词 帕金森病 焦虑 运动症状 非运动症状 Parkinson disease Anxiety Motor symptoms Non-motor symptoms
作者简介 通讯作者:张巍,Email:ttyyzw@yahoo.com.cn
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