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转录因子Oct4、Sox2在人肺癌中的表达及其临床意义 预览 被引量:9

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摘要 目的观察干细胞关键转录因子Oct4和Sox2在肺癌中的表达,探讨Oct4和Sox2的表达与肺癌病理分级和临床分期的关系。方法分别用免疫组织化学检测132例肺癌组织、42例癌旁组织及34例正常肺组织病理标本中的Oct4和Sox2表达。结果免疫组织化学显示Oct4和Sox2在肺癌组织的表达高于癌旁组织和正常肺组织,随着病理分级的升高和淋巴结转移的出现,Oct4和Sox2表达水平逐渐升高,各组间差异有统计学意义(P〈0.05),但不同分期的肺癌组织中Oct4表达差异有统计学意义(P〈0.05);Oct4或Sox2阳性与肺癌恶性表型明显相关,经过单因素及多因素分析发现Oct4或Sox2是肺癌预后的独立因素,Oct4和Sox2均阳性的患者预后最差。结论 Oct4和Sox2的表达与肺癌的分级和淋巴结转移密切相关亦与临床分期有关,Oct4的过高表达可能在肺癌的发生发展中起重要作用,Oct4和Sox2可以作为预测肺癌预后的新的分子标记。
出处 《山东医药》 CAS 2012年第20期 79-81,共3页 Shandong Medical Journal
关键词 肺肿瘤 OCT4 SOX2
作者简介 通讯作者,E—mail:hanlibo@hotmail.com
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参考文献15

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