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多烯磷脂酰胆碱联合调脂治疗非酒精性脂肪性肝病的临床观察 预览 被引量:23

Effect of polyene phosphatidyl choline combined with lipid-lowering drugs in treatment of nonalcoholic fatty liver disease
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摘要 目的探讨多烯磷脂酰胆碱联合调脂治疗非酒精性脂肪肝的临床疗效及其安全性。方法103例非酒精性脂肪肝患者随机分为治疗组(55例)和对照组(48例),治疗组应用多烯磷脂酰胆碱胶囊联合辛伐他汀治疗12周,对照组口服辛伐他汀联合维生素C和肌苷治疗12周,观察治疗前后两组患者症状及血脂、肝功能及肝脏超声影像变化。结果治疗12周,治疗组有效率为87.3%,对照组有效率为52.1%,治疗组在改善患者临床症状、肝功能及血脂方面均优于对照组,差异均有统计学意义(P〈0.05)。结论多烯磷脂酰胆碱联合调脂治疗非酒精性脂肪肝是安全有效的。 Objective To investigate the effect and safety of polyene phosphatidyl choline combined with lipid-lowering drugs in treatment of nonalcoholic fatty liver disease. Methods Total of 103 patients with nonalcoholic fatty liver disease were selected and divided randomly into two groups. In therapeutic group, the patients received polyene phosphatidyl choline combined with simvastatin (n = 55) for 12 weeks. While in control group, the patients received simvastatin, Vitamin C and inosine (n = 48) for 12 weeks. The levels of serum transaminase, clinical symptom, blood grease and image changes of B ultrasonic before and after treatment were compared, respectively. Results The levels of serum transaminase, clinical symptom, blood grease and image changes of B ultrasonic improved obviously after treatment, with the efficiency as 87.3% and 52.1% in therapeutic group and control group, respectively. There were significant difference between the two groups on the improvement of clinical symptome, liver function and blood fat (P 〈 0.05). Conclusions Treatment of nonalcoholic fatty liver disease with simvastatin combined with polyene phosphatidyl choline is safe and effective.
作者 吴春晓 陈燕鸿 周晓蕾 李林芳 WU Chun-xiao, CHEN Yan-hong, ZHOU Xiao-lei, LI Lin-fang (Department of Infectious Diseases, The People's Hospital of Zhuhai, Zhuhai 519000, China)
出处 《中国肝脏病杂志(电子版)》 CAS 2012年第2期17-20,共4页
关键词 脂肪肝 酒精性 磷脂酰胆碱类 Fatty liver, alcoholic Phosphatidyl cholines
作者简介 通讯作者:吴春晓Email:wcx139@21cn.com
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