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新疆维吾尔族与汉族乙型肝炎患者HBVDNA及肝功能检测结果的比较 被引量:1

Xinjiang Uygur, Han patients with Hepatitis B Hepatitis B Markers and Liver Function Test Results Contrast
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摘要 目的:探讨新疆乌鲁木齐地区伴有肝功能指标:丙氨酸氨基转移酶(ALT)浓度异常的维吾尔族(维族)及汉族HBeAg阳性乙型肝炎初次就诊患者,乙型肝炎病毒DNA复制载量及ALT浓度是否存在差异及其对患者诊断、预后的意义。方法:回顾性选取门诊伴有ALT浓度异常的汉族、维族初次就诊患者并筛选出HBeAg阳性患者汉族、维族共373例。采用实时荧光定量聚合酶链反应、生化测定及酶联免疫吸附试验法分别测定HBV DNA、ALT浓度及乙肝HBeAg。结果:(1)汉族HBV DNA组秩和8869,维族HBV DNA组秩和10359.36,经Mann-Whitney Test检验两组间尚不能肯定HBVDNA分布有统计学意义,即伴有肝功能损害的汉族、维族初次就诊HBeAg阳性患者HBV DNA复制程度没有差异。(2)汉族ALT组秩和26818.50,维族ALT组秩和22009.50,经Mann-Whitney Test检验两组间ALT分布有统计学意义,即伴有肝功能损害的初次就诊HBeAg阳性患者汉族肝功能损害程度高于维族。(3)HBVDNA低复制组(103-104copy/mL):汉族秩和3771.46,维族秩和4993.2;中复制组(104-106copy/mL):汉族秩和6412.4,维族秩和5088.2;高复制组(〉106copy/mL):汉族秩和929.04,维族秩和666.96,经Mann-Whitney Test检验在低复制组两民族间ALT分布无统计学意义,在中、高复制组两民族间ALT具有统计学意义。即:伴有肝功能损害的初次就诊HBeAg阳性患者在HBV DNA低复制组两民族间肝功能损害程度无差异,但在中、高复制组汉族肝功能损害程度高于维族。结论:新疆乌鲁木齐地区伴有肝功能损害的初次就诊的HBeAg阳性的汉族与维族之间HBV DNA的病毒复制无统计学意义(P〉0.05),但两民族间的ALT具有统计学意义,可能跟维族的民俗、饮食习惯及生存环境、免疫相关基因HLA基因频率分布差异等因素有关。 Objective: To explore the Xinjiang area of Urumqi accompanied by abnormal liver function of Uygur and Han(Uyghur) in HBeAg positive chronic hepatitis B patients with first visit,serological markers of hepatitis HBV DNA replication load copy number and alanine aminotransferase(ALT) levels and on whether there are differences in diagnostic,prognostic significance in patients with.Methods: A retrospective review of selected outpatients with liver function damage in patients with initial treatment of Han,Uygur and selection of HBeAg positive patients of Han nationality,a total of 373 cases of uighur.Using real-time fluorescence quantitative polymerase chain reaction(FQ-PCR) HBV DNA,chemiluminescence(CLIA) ALT levels and enzymatic e antigen qualitative determination of serum HBV in patients with DNA,CHB,ALT levels and two pairs of semi-hepatitis B.Results:(1) HBV DNA group rank: Han and Uighur group DNA 8869vs HBV rank: 10359.36,by Mann-Whitney Test tests between the two groups is still not sure HBV DNA distribution differences,is accompanied with liver function damage of the Han,Uygur initial treatment of patients with positive HBeAg HBV DNA replication levels did not differ.(2) Han HBV DNA group rank: 26818.50,Uygur HBV DNA group rank: 22009.50,by Mann-Whitney Test test ALT distribution between the two groups with significant difference,is accompanied with liver function damage in the initial treatment of HBeAg positive patients with liver function damage degree is higher than Han uygur.(3) HBV DNA low load group: Han and Uighur rank 4993.2 and rank 3771.46vs,load group: Han and Uighur rank 5088.2 and rank 6412.4vs,high load group: Han and Uighur rank rank 929.04vs and 666.96 by Mann-Whitney Test.Test at low load group of two national ALT no significant difference in the distribution of high load group of two people there was significant difference between ALT.Namely: accompanied with liver function damage of initial treatment of HBeAg positive patients in HBV DNA lo
作者 李真 杨丽 徐菲莉 刘琴 沙蕾 赵莉 LI Zhen, YANG Li, XU Fei-li, LIU Qin, SHA Lei, ZHAO Li (1 Xinjiang Medical University, 830054, Urumqi China; 2 AflTliated Hospital of Xinjiang Medical University, Urumqi, 830000,China)
出处 《现代生物医学进展》 CAS 2012年第19期3673-3677,共5页 Progress in Modern Biomedicine
关键词 HBeAg阳性乙型肝炎患者 民族 HBVDNA 丙氨酸氨基转移酶 Chronic hepatitis B HBeAg positive HBV-DNA Transaminase
作者简介 李真,女,硕士研究生,研究方向:临床分子生物学,E—mail:kuailelizhen@163.com 通讯作者:徐菲莉,女,主任检验师,硕士研究生导师,E—mail:xfl6284@163.com
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