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舒脑欣滴丸治疗急性缺血性中风73例临床观察 被引量:10

A Clinical Observation on Shunaoxin Dropping Pills for 73 Cases of Acute Ischemic Stroke
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摘要 目的观察舒脑欣滴丸治疗急性缺血性中风血瘀证的I临床疗效,并探讨其作用机制。方法选择急性缺血性中风血瘀证患者154例,随机分为对照组81例(常规治疗)和试验组73例(常规治疗+舒脑欣滴丸),两组均治疗2周。于治疗前后评价中医症状积分、卒中量表(NIHSS)评分,并检测两组患者血小板计数(PLT)、平均血小板体积(MPV)、血小板聚集率、凝血酶原时间(PT)、凝血活酶时间(APTT)、血浆凝血酶时间(TT)、纤维蛋白原(FIB)、可溶性P一选择素(sP—sel)、可溶性CD40L(sOD40L)水平。结果两组患者治疗后中医症状积分、NIHSS评分、MPV均显著减低(P〈0.05或P〈0.01);试验组治疗后血小板聚集率、sP-sel、sCD40L显著减低,APTT增加(P〈0.05或P〈O.01);治疗后试验组NIHSS评分、血小板聚集率显著低于对照组,APTT显著高于对照组(P〈0.05或P〈0.01)。结论舒脑欣滴丸可改善急性缺血性中风血瘀证患者的中医临床症状及神经功能缺损症状,其作用机制可能与抑制血小板活化、聚集,干预内源性凝血途径有关。 Objective To observe the therapeutic effect and mechanism of Shunaoxin Dropping Pill for acute ischemic stroke (AIS) with blood stasis pattern. Methods Totally 154 AIS patients with blood stasis pattern were randomized into the control group (81 cases, conventional therapy) and trail group (73 cases, conventional therapy+Shunaoxin Dropping Pill). The treat- ment lasted for 14 days. The scores of TCM symptom scale and National Institutes of Health Stroke Scale (NIHSS) were evaluated on the admission day and after treatment. The platelet count (PLT), mean platelet volume (MPV), platelet aggrega- tion rate, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), soluble P-selectin (sP-sel) and soluble CD40L (sCD40L) were detected. Results The TCM symptom scale score, NIHSS score and MPV were significantly decreased in both groups after treatment (P〈0.05 or P〈0.01). The platelet aggregation rate, sP-sel and sCD40L were significantly decreased but the APTT were significantly increased in the trail group after treat- ment (P〈C0.05 or P〈0.01). After treatment, the NIHSS score and platelet aggregation rate in the trail group were signifi- cantly lower than those in the control group, but the APTT in the trail group was significantly higher than that in the control group (P〈0.05 or P〈0.01). Conclusion Shunaoxin Dropping Pill can relieve the TCM symptoms and neurological deficit that may be relevant to inhibiting the platelet activation and aggregation and intervening the intrinsic coagulation pathway.
作者 张军平 徐媛媛 徐士欣 朱亚萍 吕仕超 仲爱芹 郝雅文 翟昂帅 ZHANG Junping , XU Yuanyuan , XU Shixin , ZHU Yaping , LV Shichao , ZHONG Aiqin , HAO Yawen , ZHAI Angshuai (1. First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193; 2. Tianj in Univer- sity of Traditional Chinese Medicine)
出处 《中医杂志》 CSCD 北大核心 2013年第9期758-761,共4页 Journal of Traditional Chinese Medicine
基金 天津市中医药管理局中医、中西医结合科研课题(11037)
关键词 舒脑欣滴丸 缺血性中风 血瘀证 卒中量表 神经功能 Shunaoxin Dropping Pill ischemic stroke blood stasis pattern NIHSS nerve function
作者简介 通讯作者:tjzhtcm@163.com
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