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长期外用他克莫司软膏对特应性皮炎患者免疫力的影响 预览 被引量:5

The Influence on Immunity in Patients with Atopic Dermatitis with Long-term Therapy by Topical Tacrolimus
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摘要 目的:探讨特应性皮炎患者长期外用他克莫司软膏治疗后血药浓度的变化以及对外周血淋巴细胞亚群的影响.方法:使用他克莫司软膏(0.1%)治疗12例特应性皮炎患者,疗程12个月,于治疗前和治疗结束后使用流式细胞术检测外周血中淋巴细胞亚群,治疗一周时和治疗结束后使用ELISA检测患者他克莫司血药浓度,比较治疗前后的变化.结果:淋巴细胞亚群的变化在治疗前后比较,差异均无统计学意义(P值均〉0.05);治疗1周时,他克莫司血药浓度为(1.73±0.48)ng/mL,治疗12个月后浓度为(1.07±0.42)ng/mL,两者差异具有统计学意义(t=16.85,P〈0.05);他克莫司软膏使用总量与Th/Ts比值变化量无相关性(r=-0.40,P〉0.05).结论:特应性皮炎长期外用他克莫司软膏存在低水平的系统吸收,他克莫司低水平系统暴露对特应性皮炎患者的外周血淋巴细胞亚群无影响. Objective: To explore the transdermal absorption of long-term topical taerolimus ointment and the influence of long-term topical tacrolimus ointment on peripheral blood lymphocyte subpopulations in patients with atopic dermatitis. Methods:12 patients with atopic dermatitis were treated with tacrolimus ointment(0. 1% ) for 12 months. Lymphocyte subpopulations was measured by flow eytometry before and after treatment respectively. Tacrolimus blood concentration was de- tected by ELISA at 1 week treatment and after treatment respectively. Results:The changes of lymphocyte subpopulations before and after treatment do not have statistical difference (P 〉 0. 05). The blood concentration of tacrolimus were ( 1.73± 0.48 ) ng/mL at 1 week of treatment and (1.07 ± 0. 42) ng/mL after 12 months of treatment. The difference showed statistical signifi- cance (P 〈 0. 05 ). Conclusion:Systemic absorption on topical tacrolimus ointment in long-term therapy were less, the blood concentration of tacrolimus does not have an impact on peripheral blood lymphocyte subpopulations of patients with atopic dermatitis.
作者 蒋冲 邓俐 陈飚 孙乐栋 张堂德 JIANG Chong, DENG Li, CHEN Biao, SUN Le-dong, ZHANG Tang-de (Department of Dermatology, Zhufiang Hospital, Southern Medical University, Guangzhou, 510282, China)
出处 《皮肤性病诊疗学杂志》 2013年第2期93-96,共4页 Southern China Journal of Dermato-Venereology
基金 2010年中华医学会皮肤性病学分会一安斯泰来皮肤病学研究基金
关键词 外用他克莫司 系统暴露 特应性皮炎 免疫力 Topical tacrolimus System exposure Atopic dermatitis Immunity
作者简介 通信作者:张堂德,E—mail:tdgz@medmail.com.cn
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  • 1Weiss HM, Fresneau M, Moenius T, et al. Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Pro- teins: Implications for Systemic Exposure after Topical Application [ J ]. Drug Metab. Dispos, 2008,36 ( 9 ) : 1812-1818. 被引量:1
  • 2Margarit C, Rimola A, Gonzalez-Pinto I, et al. Efficacy and safety of oral low-dose tacrolimus treatment in liver transplantation[J]. Transpl Int, 1998, 11 (1) : $260- $266. 被引量:1
  • 3Reitamo S, Wollenberg A, Schopf E, et al. Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group [ J ]. Arch Dermatol, 2000, 136 ( 8 ) :999-1006. 被引量:1
  • 4Wollina U. The Role of Topical Calcineurin Inhibitors for Skin Diseases Other Than Atopic Dermatitis [ J ]. Am J Clin Dermatol, 2007, 8(3) :157-173. 被引量:1
  • 5Lambers ME, Kuipers E J, van Dieren JM, et al. Local Immune Regulation of Mucosal Inflammation by Tacroli- mus[J]. Digest Dis Sci, 2010, 55(9) : 2514-2519. 被引量:1
  • 6Yago T, Nanke Y, Kawamoto M, et al. Tacrolimus po- tently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Thl7 differentiation [ J ]. Cytokine ,2012 ,59 (2) : 252-257. 被引量:1
  • 7Kurtoglu EL, Yuksel S. Genotoxic effects of tacrolimus on human lymphocyte cells [ J]. Rus J Genet, 2012,48 (6) :762-767. 被引量:1
  • 8Kim TJ, Kim N, Kang HJ, et al. FK506 causes cellular and functional defects in human natural killer cells[J]. J Leukoc Biol,2010,88 (6) : 1089-1097. 被引量:1
  • 9Pate1 TS, Greer SC, Skinner RB Jr. Cancer concems with topical immunomodulators in atopic dermatitis: over- view of data and recommendations to clinicians [ J ]. Am J Clin Dermatol. 2007,8(4) :189-194. 被引量:1
  • 10Spergel JM, Leung DY. Safety of topical calcineurin in- hibitors in atopic dermatitis: Evaluation of the evidence [ J]. Cur Allergy Asthma Rep, 2006, 6(4) : 270-274. 被引量:1

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