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依达拉奉联合神经节苷脂早期治疗急性脑梗死的临床分析 被引量:32

Clinical Analysis of Early Applying Edaravone and Monosialotetrahexosylganglioside in Acute Cerebral Infarction
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摘要 目的观察依达拉奉联合单唾液酸四己糖神经节苷脂治疗急性脑梗死的临床疗效。方法选择70例发病时间在72h内的急性脑梗死患者,随机分为治疗组35例,对照组35例。治疗组在对照组基础上加用依达拉奉30mg加入0.9%氯化钠注射液100ml静脉滴注,每天2次,连用14d。对照组给予基础治疗和唾液酸四己糖神经节苷脂40mg加入0.9%氯化钠注射液150ml静脉滴注,每天1次,连用14d。比较两组治疗前后的患者临床神经功能缺损程度评分和临床疗效。结果治疗前两组临床神经功能缺损评分无明显差异。治疗14d后,治疗组评分低于对照组。治疗组临床疗效总有效率为91.4%,对照组为71.1%,差异有统计学意义(P=0.016)。结论依达拉奉联合单唾液酸四己糖神经节苷脂早期治疗急性脑梗死有显著疗效。 Objective To observe the therapeutic effects of edaravone and monosialotetrahexosylganglioside on acute cerebral infarction.Methods Seventy cases of acute cerebral infarction patients admitted to hospital 72h after onset were randomly divided into treatment group and control group.The treatment group were intravenously given edaravone by drops(30mg edaravone were added to 100ml physiological saline),twice a day for 14 days.The control group were given the same treatments and intravenous monosialotetrahexosylganglioside by drops(40 mg monosialotetrahexosylganglioside were added to 150ml physiological saline),once a day for 14 days.Conditions of both groups before and after the treatment were evaluated by clinical neurological deficit scores and were compared with each other.Results Fourteen days after treatment,clinical neurological deficit scores of the treatment group were significant lower than that of the control group,both obvious effects and effects rates of the treatment group were significant higher than that of the control group 14d after treatment.Conclusion Edaravone and monosialotetrahexosylganglioside is effective to treat acute cerebral infarction without any serious adverse reaction being observed.
作者 周艳 孙宏侠 张明明 ZHOU Yan ,SUN Hong-xia ,ZHANG Ming-ming. ( Jilin Provincial People' s Hospital, Changehun 130021, China)
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2013年第5期419-421,共3页 Journal of Apoplexy and Nervous Diseases
关键词 脑梗死 依达拉奉 疗效 Edaravone Acute cerebral infarction Effect
作者简介 通讯作者:周艳,E-mail:997375342@qq.com
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