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穴位埋入药线联合李可“乌蛇荣皮汤”治疗寻常型银屑病的临床疗效及其对CD4^+和CD8^+ T细胞的影响 预览 被引量:9

urative Effect of Acupoint - embedding Therapy with Catgut of Traditional Chinese Medicine Combined with LI KeWushe Rongpitang on Psoriasis Vulgaris and Its Influence on the Transformation of CD4 + and CD8 + T - lymphocyte
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摘要 目的观察穴位埋入药线联合李可“乌蛇荣皮汤”治疗寻常型银屑病的临床疗效,探讨其对CD4 +和CD8+/T细胞的影响。方法选择2004年9月-2011年12月本院收治的寻常型银屑病(风热血燥型白疤)患者共106例,采用分层随机分组方法分为对照组30例和试验组76例,同时选取与试验组患者相匹配的健康人30例为健康对照组。对照组采用复方氨肽素片进行治疗,试验组采用穴位埋入药线联合李可“乌蛇荣皮汤”进行治疗;两组疗程均为8周。观察两组患者严重程度指数(PASI)变化并评价临床疗效,检测试验组患者治疗前后CD4 +和CD8+T细胞水平并与健康对照组进行比较。结果治疗前对照组PAa为(17.79 ±7.36),试验组为(18.46 ±7.28),差异无统计学意义(t=0.43, P〉0.05);治疗后对照组PASI为(7.46 ±2. 63),试验组为(4.82±2.78),差异有统计学意义(t=4.47,P〈0.001)。试验组总有效率(88.2%,67/76)高于对照组(63.3%, 19/30),差异有统计学意义(χ^2 =8.66,P〈0. 01).试验组治疗前CD4 +和CD8+T细胞水平与健康对照组比较,差异均有统计学意义(P〈0.01);试验组治疗后CD4+T细胞水平与健康对照组比较,差异无统计学意义(P〉0.05), CD8+T细胞水平与健康对照组比较,差异有统计学意义(P〈0.01)。结论穴位埋入药线联合李可“乌蛇荣皮汤”治疗寻常型银屑病具有较好的临床疗效,可提高患者CD4+T细胞水平,改善患者免疫功能。 Objective To investigate the curative effect of acupoint - embedding therapy with catgut of TCM combined with O Ke Wushe rongpitang and its influence on CD4 + and CD8 + T - lymphocyte in the treatment of psoriasis vulgaris. Methods106 cases of psoriasis (wind - heat and blood dryness type) admitted to our hospital from September 2004 to December 2011were randomly divided into control group (30 cases) , treated only with Di Yin Pian, and experiment group (76 cases) , treated with acupoint - embedding therapy with catgut of TCM and LI Ke Wushe rongpitang. After 8 weeks of continuous treatments,the clinical curative effects were evaluated according to the severity index ( PASI) . The CD4 + and CD8 + T - lymphocyte levelswere determined before and after treatment in the experiment group. A comparison was made between the two groups and with thatof the group of thirty healthy people. Results The PASI before treatment in control group and experimental group was (17. 79±7. 36) and (18. 46 ±7. 28) , respectively, and the difference was not statistically significant (t = 0.43, P 〉 0. 05) . Aftertreatment, the figure was (7. 46 ±2.63) and (4. 82 ±2.78) respectively, and the difference was statistically significant (t =4. 47,P 〈0. 001 ) . The curative effect of the experiment group and control group, (88. 2%,67/76) and (63. 3%,19/30)respectively, showed statistically significant difference (χ^2 = 8. 66, P 〈 0. 01 ) . Before treatment, the CD4 + and CD8 + T -lymphocyte in experiment group showed statistically significant difference compared with the healthy control group (P 〈 0. 01 ).However, after treatment, the CD4 + T - lymphocyte in experiment group showed no statistically significant difference comparedwith the healthy control group (P 〉0. 05),but CD8 + T - lymphocyte showed (P 〈0. 01) . Conclusion It is effective to treatpsoriasis vulgaris and improve the immunoregulatory function with acupoint - embedding therapy with catg
作者 雷鸣 赵同民 刘延菊 吴文华 LEI Ming,ZHAO Tong - min,LIU Yan -ju,et al. Langfang Medicine School,Langfang 065001,China
出处 《中国全科医学》 CAS CSCD 北大核心 2013年第18期2188-2190,共3页 Chinese General Practice
关键词 药线 乌蛇荣皮汤 银屑病 T淋巴细胞 Medicated threads; Wushe rongpitang; Psoriasis; T - lymphocyte
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