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孕期十溴联苯醚暴露对子代大鼠空间学习记忆能力的影响 被引量:3

Effects of Prenatal Exposure to Decabromodiphenyl Ether on Learning and Memory in Rat Offspring
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摘要 [目的]观察孕期十溴联苯醚(Decabromodiphenyl ether,BDE-209)暴露对子代大鼠活动能力及空间学习记忆能力的影响。[方法]将SD孕鼠随机分为对照组和100、300、900mg/kg BDE-209染毒组。于妊娠第6~20天期间,3个染毒组分别每天灌胃BDE-209染毒,对照组采用玉米油灌胃,连续15d。采用旷场实验观察子代大鼠活动能力,采用Morris水迷宫实验检测大鼠空间学习及记忆能力。[结果](1)旷场实验表明:各组子代大鼠在旷场中活动的总距离差异无统计学意义(雌性子代大鼠,F=2.13,P〉0.05;雄性子代大鼠,F=0.70,P〉0.05)。(2)Morris水迷宫实验表明:在隐蔽平台实验中,训练第3天,雌性子代大鼠的300mg/kg和900mg/kg染毒组与对照组相比,逃避潜伏期延长,差异具有统计学意义(P〈0.01);而雄性子代大鼠各组差异无统计学意义(P〉0.05)。在空间探索实验中,雄性子代大鼠各组间平台象限活动时间的差异有统计学意义(F=4.17,P〈0.01),其中100mg/kg和300mg/kg染毒组与对照组相比,平台象限活动时间缩短,其差异有统计学意义(P〈0.01);而雌性子代大鼠各组间差异无统计学意义(P〉0.05)。[结论]孕期BDE-209暴露对子代大鼠活动能力无明显影响,可能导致雌性子代大鼠空间学习记忆能力下降和雄性子代大鼠空间位置记忆能力下降。 [Objective]To investigate the effects of prenatal exposure to decabromodiphenyl ether(BDE-209) on learning and memory as well as locomotor activity in rat offspring.[Methods]Pregnant SD rats were randomly treated with BDE-209(100,300,and 900mg/kg) or corn oil on gestational days 6-20.Behavioral performances of all the groups were evaluated by open field test and Morris water maze test.[Results]1) In the open field test,no significant difference in travelled distance was found among all the groups(female offspring,F=2.13,P0.05;male offspring,F=0.70,P0.05).2) In the hidden platform trials of Morris water maze experiment,the latency periods were significantly prolonged in the female offspring prenatally administered with 300mg/kg and 900mg/kg BDE-209 compared to the controls(P 〈0.01),but no significant difference was observed in the male offspring(P 〈0.05).The results of probe trails showed that the male offspring presented statistically significant changes in the time spent in targeted quadrant(F=4.17,P 〈0.01);compared to the controls,the 100mg/kg and the 300mg/kg male offspring groups showed significantly decreased time spent in targeted quadrant,but no significant difference was observed among the female offspring groups(P 〈0.05).[Conclusion]Prenatal exposure to decabromodiphenyl ether may cause spatial learning and memory impairments in female rat offspring,and no changes in locomotor activity was observed in both genders.
作者 谢欣 周义军 高宇 梁辰 陈丽梅 何晓雯 施蓉 田英 XIE Xin,ZHOU Yi-jun,GAO Yu,LIANG Chen,CHEN Li-mei,HE Xiao-wen,SHI Rong,TIAN Ying (School of Public Health,Shanghai Jiao Tong University,Shanghai 200025,China)
出处 《环境与职业医学》 CAS 北大核心 2013年第7期515-519,共5页 Journal of Labour Medicine
基金 国家自然科学基金(编号:81172625) 上海交通大学医学院自然科学基金项目(编号:12XJ10043) 上海交通大学医学院自然科学基金项目(编号:12zr1416100) 上海市公共卫生重点学科建设项目(编号:12GWZX0401)
关键词 十溴联苯醚 旷场实验 MORRIS水迷宫 学习记忆能力 大鼠 decabromodiphenyl ether open field test Morris water maze learning and memory ability rat
作者简介 谢欣(1987-),男,硕士生;研究方向:环境毒理学,环境流行病学;E-mail:xiex0001@gmail.com [通信作者]田英教授,E—mail:tianmiejp@yrahoo.com.cn
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参考文献15

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