Objective： To explore reverse vascular remodeling effect and possible mechanism in climacteric hypertension rats with Xuzao Gengping Powder. Methods： Climacteric hypertension model rats were established and randomly divided into traditional Chinese medicine group, western medicine group, climacteric hypertension group, fake operation and SHR groups. WKY group was set as a normal control group. The traditional Chinese medicine group was drenched with Xuzao Gengping powder, and the western medicine group with Valsartan Capsule. The other groups were drenched with distilled water. Results： The vascular remodeling of climacteric hypertension rats was more serious than SHR rats＇. There was no difference between climacteric hypertension traditional Chinese medicine and climacteric hypertension western medicine, and both of them were smaller than WKY, MT, MT/LD decreased （P〈0.05）. The traditional Chinese medicine group and western medicine group were larger than WKY（P〈0.05）. Compared with the climacteric hypertension, fake operation and SHR groups, MMP-9 and TIMP- 1 levels in serum of traditional Chinese medicine group and western medicine group decreased （P〈0.05）. Conclusion： Xuzao Gengping Powder can significantly reduce vascular tissue damage caused by high blood pressure. By reducing MMP-9 and TIMP- 1 in serum and restoring balance of MMP-9/TIMP-1 might be the effective mechanism for preventing and reversing vascular remodeling in climacteric hypertension rats.
China Journal of Traditional Chinese Medicine and Pharmacy