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江苏省≥15岁居民麻疹免疫水平分析 被引量:10

Immunity to measles virus in population aged ≥15 years in Jiangsu province
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摘要 目的 调查≥15岁居民麻疹免疫水平并探讨阻断麻疹传播策略。方法 对江苏省603名≥15岁居民麻疹免疫水平进行血清流行病学调查,分离血清后采用酶联免疫吸附试验检测抗体,抗体阳性率比较运用χ2检验。结果 2012年共收集603份合格标本,苏北、苏南抗体阳性率分别为91.33%、95.36%,男、女性抗体阳性率分别为92.24%、95.69%,≥15岁居民抗体阳性率为94.36%,不同地区、性别、年龄居民抗体阳性率差异均无统计学意义,与2008年比较差异均无统计学意义;≥15岁居民麻疹几何平均滴度(GMT)随年龄增长呈下降趋势。结论 以8月龄-14岁儿童为对象的免疫策略对≥15岁居民麻疹发病影响较小,无法阻断麻疹病毒在全省范围内传播。 Objective To investigate the immunity to measles virus in population aged ≥15 years in Jiangsu province and to explore stratiges for interrupting measles virus transmission.Methods Sero-survey on measles IgG antibody in 603 individuals aged ≥15 years in Jiangsu province was carried out,and the antibody was detected using enzyme-linked immunosorbent assay.Chisq-test was used to measure the differences in antibody positive rate.Results Totally 603 specimens were collected.The antibody seroprevalence of the populations in northern and southern were 91.33% and 95.36%;the seroprevalence of male and female were 92.24% and 95.69%;the seroprevalence of population aged ≥15 years in 2012 was 94.36%.There were no statistical differences in the positive rate among region,gender,and age groups.And no statistical difference in the positive rate of the population in 2012 was found when compared to that of 2008.The geometric mean titer in the population of ≥15 years decreased with age.Conclusion The immunization strategies targeted to the individuals aged 8 months to 14 years may not work to interrupt measles virus transmission,especially in the individuals aged ≥15 years.
作者 刘元宝 陆培善 周春宁 胡莹 邓秀英 汪志国 马福宝 陶红 贾成梅 LIU Yuan-bao, LU Pei-shan, ZHOU Chun-ning, et al Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province 210009, China
出处 《中国公共卫生》 CAS CSCD 北大核心 2013年第12期1842-1844,共3页 Chinese Journal of Public Health
基金 江苏省预防医学科研课题(Y2012068)
关键词 麻疹 血清流行病学 抗体阳性率 measles seroepidemiology antibody positive rate
作者简介 作者简介:刘元宝(1982-),男,山东临沂人,主管医师,硕士,研究方向:免疫规划相关传染病防控。
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