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四逆散、二仙汤及其合剂对慢性应激合并乳腺增生模型大鼠的影响 预览 被引量:14

Comparative Study of "Sini San" and "Erxian Decoction"on Rats with Chronic Psychological Stress and Mammary Hyperplasia Disease (MHD)
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摘要 目的根据女性乳腺增生的发病与中医情志致病理论密切相关的特点,利用现代医学心身医学的理论与方法,探索复合因素即肝气郁滞兼冲任失调乳腺增生病证结合动物模型的造模方法,及中药治疗效果。方法随机将70只雌性未孕大鼠分为正常组10只,模型组15只,四增应组15只,二增应组15只,四加二增应组15只,采用慢性应激合并乳腺增生模型的造模方法,观察造模期间动物的行为学变化,造模后动物乳头组织高度并采用放免法检测血清等指标。结果造模方法对动物行为影响较大,各中药组治疗后动物体力和活动均有所改善,乳腺组织增生缓解。给予二仙汤、四逆散分煎及合煎治疗后,血清指标均有所恢复,组间无显著差异,合煎液较分煎液更降低E2/P比值,缓解乳腺组织增生程度。结论四逆散、二仙汤均能缓解大鼠乳腺增生。慢性应激与乳腺增生复合造模,复制出病证结合动物模型产生了乳腺增生的效果,四逆散与二仙汤合煎与分煎在血清指标上无显著差异,调节雌/孕激素平衡作用合煎较分煎效果明显。 OBJECTIVE To explore effect of Chinese medicine on animal models with mammary hyperplasia disease induced by liver qi stagnation and Chong and Ren pulses disorder in the theory and method of psychosomatic medicine in modern medicine, according to the characteristic of setup of female breast hyperplasia closely related to the theory of pathogenic emotion leading to diseases in TCM. METHODS Combination of chronic stress and mammary hyperplasia was used to make models, during which the behavior changes, animal tissue papilla height after modeling were observed. And serum was detected in ra- dioimmunoassay. RESULTS The modeling method made a big difference on animal behavior. Animal strengh and behavior were improved in each TCM group after treatment and breast tissue hyperplasia was relieved. After treatment with Erxian de- coction, Sini powder and the combination, serum indexed were recovered and there were no significant difference among the groups. The ratio in group with the combination was lower E2/P than that in group with seperated medicine. The hyperplasia was relieved in some degree. CONCLUSION Sini powder and Erxian decoction can improve breast hyperplasia in rats. Chronic stress and breast hyperplasia combined with animal models have induced the effect of breast hyperplasia. Sini powder, Erxian decoction and the combination make no significant differences in serum indicators; in terms of adjusting balance between estrogen and progesterone, the combination is better than the seperated.
作者 宋婷 童钟 李中平 沈红艺 SONG Ting1 ,TONG Zhong2 , LI Zhong-ping3 , SHEN Hong-yi3. (1 .College of Basic Medicine, Shanghai University of Chinese Medicine, Shanghai, 201203, China; 2. Guangdong Provin cial Work Injury Rehabilitation Center, Guangzhou, 510970, China; 3 .Department of Health Nutrition Shanghai Universi ty of Chinese Medicine Shanghai, 201203, China)
出处 《南京中医药大学学报》 CAS CSCD 北大核心 2014年第1期57-60,共4页 Journal of Nanjing University of Traditional Chinese Medicine(Natural Science)
基金 上海市教委资助项目(20LOJW29) 上海中医药大学校级健康营养基金(L1230)
关键词 慢性应激 乳腺增生 疏肝解郁 调理冲任 chronic stress mammary hyperplasia soothing liver and releasing depression regulating Chong and Ren pulses
作者简介 宋婷(1986-),女,江西德兴人,上海中医药大学2011级博士研究生。 通信作者:xhhc1503@sina.com
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