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艾司西酞普兰与帕罗西汀治疗伴焦虑症状的抑郁症随机对照研究 被引量:20

A Randomized Controlled Study of the Efficacy and Safety of Escitalopram and Paroxetine in Treatment of Major Depressive Disorder with Anxiety
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摘要 目的探讨艾司西酞普兰治疗伴焦虑症状抑郁症的疗效和安全性。方法采取随机对照研究方法,78例伴焦虑症状的抑郁症患者纳入研究,研究组服用艾司西酞普兰治疗,对照组服用帕罗西汀治疗,疗程6周。采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)进行疗效评定,采用副反应量表(TESS)对不良反应评估。结果研究组和对照组的有效率分别为52.5%和52.6%(P〉0.05),临床治愈率分别为87.5%和86.8%(P〉0.05);研究组恶心、心悸、头晕三项不良反应发生率(2.5%、2.5%、5%)均低于对照组(15.8%、18.4%、21.0%),差异有统计学意义(P〈0.05)。结论艾司西酞普兰治疗伴焦虑症状的抑郁症疗效与帕罗西汀相当,个别不良反应发生率低于帕罗西汀。 Objective To investigate the efficacy and safety of escitalopram in treatment of major depressive disorder with anxiety. Methods This was a randomized controlled study. A total of 78 depression patients with anxiety randomized to study group with escitalopram or control group with paroxetine for 6weeks. The changes in total score of the Hamilton Depression Scale 17 item( HAMD17) and Hamilton Rating Scale for Aniety( HAMA)were used to evaluate the therapeutic effect in treatment. Treatment Emergent Symptom Scale( TESS) was used to evaluate the adverse effect. Result The response rates of the two groups were 87. 5%( study group) and 86. 8%( control group)( P>0. 05),while the clinical cure rates were52. 5%( study group) and 52. 6%( control group)( P>0. 05). The adverse events of nausea,heart-throb and dizzy in study group( 2. 5%,2. 5%,2. 5%) were significantly lower than in control group( 15. 8%,18. 4%,21. 0%)( P<0. 05). Conclusion Escitalopram and paroxetine have similar therapeutic effect in treatment of depression patients with anxiety,but escitalopram causes less aderse events.
作者 向东方 牟艳丽 赵贤玲 张淑芳 Xiang Dongfang, Mou YanLi, Zhao Xianling, et al. Wuhan Mental Health Center Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
出处 《国际精神病学杂志》 2014年第1期8-11,共4页 Journal Of International Psychlatry
关键词 艾司西酞普兰 帕罗西汀 抑郁症 疗效 Escitalopram Paroxetine Depressive Efficacy
作者简介 向东方(1974-),男,武汉人,主治医师,研究方向:抑郁障碍的药物及心理治疗。
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