期刊文献+

GP73和AFP单项与联合诊断对原发性肝癌诊断应用的Meta分析 被引量:16

Diagnostic value of Golgi-73 and AFP in primary hepatocelluar carcinoma with single assay orcombined detection: a meta-analysis
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摘要 目的系统评价AFP、GP73单项检测,GP73和AFP联合检测在原发性肝癌中的临床诊断价值。方法Meta分析。检索PubMed、西文生物医学期刊文献数据库、维普中文科技期刊数据库、万方数据知识服务平台自建库至2013年6月国内外发表的关于AFP、GP73单项检测,GP73和AFP联合检测原发性肝癌诊断性实验的文献,同时手检纳入文献的参考文献,并按纳人标准与排除标准筛选文献,提取数据,同时根据诊断性研究的质量表(QUADAS)评价符合纳人标准的文献质量,通过Meta分析合并诊断效应量及绘制综合受试者工作曲线(SROC)。统计分析AFP、GP73,GP73联合和AFP检测诊断原发性肝癌的敏感度、特异度、诊断性试验比值比(DOR)及95%可信区间。结果共纳入符合标准的中英文文献27篇。AFP汇总的敏感度、特异度、DOR及95%可信区间分别为0.58(0.56~0.60)、0.85(0.84~0.87)、12.57(8.60~18.36).GP73为0.76(0.74~0.77)、0.82(0.81~0.83)、19.14(13.70~26.75),GP73币口AFP联合为0.86(0.84~0.88)、0.80(0.78~0.82)、40.60(28.49~57.87)。AFP、GP73单项检测,GP73和AFP联合检测的汇总受试者工作特征曲线下面积(AUC)分别为0.8371、0.8812和0.9294,Z检验比较AFP、GP73单项检测的AUC差异无统计学意义(P〉0.05),而AFP、GP73分别与GP73和AFP联合检测的AUC差异有统计学意义(P〈0.05)。结论AFP、GP73单项检测在诊断原发性肝癌时均具有较好的准确性,但GP73和AFP联合检测可显著提高肝癌诊断的准确性,能有效避免一些AFP阴性漏检病例。(手华检验医学杂志,2014,37:378-382) Objective To evaluate the diagnostic accuracy of Golgi protein -73 (GP73) and AFP in single and combining forms for primary hepatocelluar carcinoma. Methods By searching PubMed, Foreign Medical Journal Full-Text Service, Wanfang and VIP database from inception to June 2013, combined additional manual tracking, both Chinese and English literatures about GP73 and AFP in the diagnosis of primary hepatocellular carcinoma were retrieved then literatures were selected according to the inclusion and exclusion criteria. Quality assessment of diagnostic accuracy studies ( QUADAS ) items were used to evaluate the quality of literatures. Sensitivity, specificity and diagnostic odds ratio (DOR) were pooled using random-effect model. Summary receiver operating characteristic curve analysis was used to evaluate the diagnostic accuracy of GP73 and AFP in single and combining forms. Results Totally 27 literatures in English or Chinese were enrolled into this study. The pooled sensitivity, specificity and DOR [95% confidence interval (CI)] of AFP alone were 0.58 (0.56-0.60), 0.85 (0.84-0.87), 12.57 (8.60-18.36); while for those of GP73 alone were, 0.76 (0.74-0.77), 0.82(0.81-0.83), 19. 14 ( 13.70-26.75 ) ; and for those of GP73 combined with AFP were, O. 86 (0. 84-0. 88 ) , O. 80 (0.78-0. 82), 40. 60 (28.49-57.87). The area under summary receiver operating characteristics curve were O. 837 1, 0. 881 2 and 0. 929 4, respectively. And there was no significant difference of AUC between GP73 and AFP in single tests by Z test ( P 〉 0. 05 ) , however, significant difference of AUC was found between GP73 combined with AFP and single tests (P 〈 0. 05 ). Conclusion Both AFP and GP73 are useful fordiagnosing of primary hepatocelluar carcinoma, but GP73 combined with AFP detection can significantly improve the diagnostic accuracy, and some primary hepatocelluar carcinoma cases with AFP negative can be avoided missing efficiently by parallel diagnostic test. (Chin J Lab Med,20
作者 万豪光 徐浩 顾玉明 王慧 许伟 祖茂衡 王勇 宗迎迎 Wan Haoguang, Xu Hao, Gu Yuming, Wang Hui, Xu Wei, Zu Maoheng, Wang Yong, Zong Yingying.( Department of Interventional Radiology, Aj~iliated Hospital of Xuzhou Medical College, Xuzhou 221002, China Corresponding author : Xu Wei, Email : xuwei0202 @ gmail com)
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2014年第5期378-382,共5页 Chinese Journal of Laboratory Medicine
关键词 肝细胞 膜蛋白质类 甲胎蛋白类 肿瘤标记 生物学 META分析 Carcinoma, hepatocelluar Membrane proteins alpha-Fetoproteins Tumormarkers, biological Meta-analysis
作者简介 许伟,电子信箱:xuwei0202@gmail.com
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