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莪术对肾脏细胞外基质影响的实验研究 预览 被引量:49

Experimental Study on the Influence of Curcumae on Extracellular Matrix of Kidney
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摘要 为探讨莪术对慢性肾炎、肾功能不全的作用机理.将24只SD大鼠分为假手术组(A)、模型组(B)、中药组(C)3组,对B、C组大鼠制成单侧输尿管梗阻(UU0)模型,C组大鼠用莪术煎剂灌胃.6d后处死动物,观察肾间质CD8+T细胞,ECM型胶原Ⅲ、Ⅳ及纤维连结蛋白(FN)、层粘连蛋白(LN)、α-平滑肌肌动蛋白(α-SMA)和转化生长因子β(TGF-β)的表达.结果:C组的各项指标均有显著性变化(P<0.05~0.01).提示莪术通过影响高凝状态促进ECM降解,减少CD8+T细胞浸润和影响TGF-β等细胞因子的产生,防止或减少了ECM过度积聚,从而改善了肾功能. To investigate the mechanism of curcumae in the prevention and treatment of chronic nephritis and renal insufficiency,24 SD rats were classified into group A,group B and group C.Rats in group B and C were made to have unilateral ureteral obstruction(uuo).In addition,the rats in group C were treated by pouring curcumae decoction into stomach.6 day later,the rats were sacrificed,and the expressions of CD 8 +T cells,collagen fibers Ⅲ and Ⅳ,fibronectin(FN),laminin(LN),α smooth muscle actin(α SMA)and transformation growth factor β(TGF β)were observed.Results showed that the indexes in group C were improved obviously( P <0.05~0 01),indicating that curcumae could degrade the extracellular matrix,reduce the infiltration of CD 8 +T cells and influence the production of TGF β to improve the renal function.
作者 杜兰屏 胡仲仪 邓跃毅 陈以平 Longhua Hospital Affiliated to Shanghai University of TCM DU Lan pingHU Zhong yiDENG Yue yiCHEN Yi ping
出处 《上海中医药杂志》 北大核心 2001年第6期 38-40,共3页 Shanghai Journal of Traditional Chinese Medicine
关键词 莪术 慢性肾炎 肾功能不全 肾脏细胞外基质 动物实验 ECM Curcumae chronic nephritis renal insufficiency extracellular matrix of kidney animal experiment
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