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化瘀软肝汤对代偿期乙型肝炎肝硬变患者肝脏功能及凝血功能的影响 被引量:2

Effect of Huayu Ruangan Decoction on Liver Function and CoagulationFunction in Patients with Compensatory Hepatitis B Cirrhosis
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摘要 目的:观察化瘀软肝汤治疗代偿期乙型肝炎(简称乙肝)肝硬变患者的临床疗效及对患者肝脏功能、凝血功能的影响。方法:100例乙肝肝硬变代偿期患者按照随机数表法分为对照组和观察组,每组各50例。对照组给予恩替卡韦治疗,观察组在对照组治疗的基础上给予化瘀软肝汤治疗,两组患者均连续治疗1年。比较两组患者临床疗效、中医证候评分及不良反应的发生情况。比较两组患者治疗前后血清谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate transaminase,AST)及血清总胆红素(serum total bilirubin,STB)水平。检测并比较两组患者治疗前后血浆凝血酶原时间(prothrombin time,PT)、活化部分凝血酶原时间(activated partial thromboplastin time,APTT)、凝血酶原固定时间(thrombin time,TT)及纤维蛋白原(fibrinogen,Fib)水平。结果:观察组患者有效率为96.00%(48/50),对照组为70.00%(35/50),两组比较,差异有统计学意义(P<0.05)。治疗后两组患者中医证候评分均明显低于治疗前,且观察组治疗后中医证候评分低于对照组(P<0.05)。与治疗前比较,两组患者治疗后血清ALT、AST及STB水平均明显降低;观察组治疗后以上指标均低于对照组(P<0.05)。与治疗前比较,两组患者治疗后PT、APTT、TT水平降低,Fib水平升高;观察组患者治疗后PT、APTT、TT水平低于对照组,Fib水平高于对照组(P<0.05)。两组治疗过程中均未出现严重的不良反应。结论:化瘀软肝汤治疗代偿期乙肝肝硬变患者临床疗效显著,能够明显减轻患者临床症状,改善肝功能和凝血功能,且无严重不良反应。 Objective: To observe the effect of Huayu Ruangan Decoction on liver function and coagulation function in patients with compensatory hepatitis B cirrhosis. Methods: 100 patients with compensated hepatitis B cirrhosis were divided into control group and observation group according to the random number table method,50 cases in each group. The control group was treated with entecavir,and the observation group was given Huayu Ruangan Decoction on the basis of the treatment of the control group. Both groups were treated continuously for 1 year. The clinical efficacy,TCM syndrome scores and adverse reactions of the two groups were compared. The levels of serum alanine aminotransferase ( ALT) ,aspartate transaminase ( AST) and serum total bilirubin ( STB) in both groups were compared before and after treatment. The levels of plasma prothrombin time ( PT) ,activated partial thromboplastin time ( APTT) , thrombin time ( TT) , and fibrinogen ( Fib) in both groups were detected and compared before and after treatment. Results: The effective rate was 96. 00% ( 48 /50) in the observation group and 70. 00% ( 35 /50) in the control group. The difference was statistically significant ( P < 0. 05) . After treatment,the TCM syndrome scores of the two groups were significantly lower than before treatment,and the TCM syndrome scores of the observation group were lower than the control group ( P < 0. 05) . Compared with before treatment,serum ALT,AST and STB levels were significantly lower after treatment in both groups. The above indicators were lower in the observation group than in the control group ( P < 0. 05) . Compared with before treatment,the levels of PT,APTT and TT decreased and the level of Fib increased after treatment. The levels of PT,APTT and TT in the observation group were lower than those in the control group,and the Fib level was higher than that in the control group ( P < 0. 05) . No serious adverse reactions occurred during the treatment of the two groups. Conclusion: Huayu Ruangan Decoction has significant clin
作者 余晓珂 任平 胡清伟 YU Xiaoke;REN Ping;HU Qingwei(The Third Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450008;Henan University of Chinese Medicine,Zhengzhou Henan China 450046;Chinese Medicine Hospital of Chongqing City Banan District,Chongqing China 400055)
出处 《中医学报》 CAS 2018年第11期2222-2225,共4页 Journal of Henan University of Chinese Medicine
基金 河南省科技厅基金项目(142300410070).
关键词 化瘀软肝汤 乙肝肝硬变 肝脏功能 凝血功能 恩替卡韦 中西医结合 Huayu Ruangan Decoction hepatitis B cirrhosis liver function coagulation function entecavir integration of traditional and western medicine
作者简介 余晓珂(1982-),女,河南鹤壁人,医学硕士,主治医师,研究方向:中医药治疗消化系统疾病;通信作者:胡清伟(1971-),男,副主任医师。Email:932255160@qq.com.
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