Objective:To provide evidence for Chinese medicine treatment of youth with EB virus infection by exploring its clinical efficacy from multiple angles.Methods:Totally 92 youth patients were randomly assigned to the treatment group(51 cases) and the control group(41 cases).Patients in the treatment group took Chinese medicine,while those in the control received intravenous dripping of Ganciclovir and oral administration of pidotimod.The treatment period for the two groups was 2 weeks.Patients were followed-up till the 4th week.Clinical symptoms such as skin rashes,jaundice,transaminase elevation,weak,pharyngalgia,as well as lab indices such as immunoglobulin and lymphocyte subclass were observed before and after treatment at week 4 and 12 of follow-ups.Results:(1)The total effective rate at week 2 was 96.1% in the treatment group,higher than that of control group(95.1%),but there was no statistical difference between them.(2)The time for fever,weak,jaundice and transaminase elevation was shorter in the treatment group than that in control group(P<0.05).(3)The positive cases of peripheral blood hetero-lymphocyte was significantly reduced after treatment at week 1 and 4 of follow-ups both in the two groups(P<0.01).The expressions of IgA,IgM and IgG decreased after treatment in the two groups when compared with those before treatment in the two groups(P<0.05,P<0.01).(4)After treatment,at week 1 and 4 of follow-ups,CD3^+ and CD8^+ decreased.CD4^+ and CD4/CD8 increased in the two groups hen compared with those before treatment(P<0.05).(5)B cells and NK cells increased more in the treatment group after treatment at week 1 and 4 of follow-ups,higher than that before treatment as well as those of the control group(P<0.05).Conclusion:Treatment of EB virus infection in youth by Chinese medicine was effective and it could promote the recovery of infection,and reduce the risk of vicious disease after infection.
Liaoning Journal of Traditional Chinese Medicine