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中药治疗青年EB病毒感染的疗效评价及其免疫干预的机理研究

Chinese Medicine Treatment of Youth with EB Virus Infection
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摘要 目的:多指标研究中药治疗青年EB病毒感染的疗效。方法:92例青年患者随机分为治疗组51例和对照组41例,中药组口服中药汤剂2周,西药组口服匹多莫德胶囊并滴注更昔洛韦注射液2周,观察治疗前后及随访第1、4周的发热、皮疹、黄疸、转氨酶升高、乏力、咽痛症状,以及免疫球蛋白、淋巴细胞亚类等指标。结果:①治疗组总有效率96.1%,对照组95.1%,两组差异无统计学意义;②治疗组的发热持续时间、乏力持续时间、黄疸持续时间,转氨酶升高持续时间均短于对照组,差异有统计学意义(P<0.05);③与治疗前相比,两组在治疗后及随访的第1、4周,末梢血常规异常淋巴细胞阳性数均明显减少(P<0.01);两组的IgA、IgM、IgG均在治疗后下降(P<0.05,P<0.01);④与本组治疗前比较,两组在治疗后及随访的第1、4周时,CD3^+和CD8^+均下降(P<0.05),CD4^+和CD4/CD8均上升(P<0.05);⑤治疗组的B细胞和NK细胞在治疗后及随访的第1、4周均有升高,高于本组治疗前(P<0.05),且高于对照组(P<0.05)。结论:中药治疗青年EB病毒感染的疗效好,可以促进恢复,减少发生恶性疾患的机会。 Objective:To provide evidence for Chinese medicine treatment of youth with EB virus infection by exploring its clinical efficacy from multiple angles.Methods:Totally 92 youth patients were randomly assigned to the treatment group(51 cases) and the control group(41 cases).Patients in the treatment group took Chinese medicine,while those in the control received intravenous dripping of Ganciclovir and oral administration of pidotimod.The treatment period for the two groups was 2 weeks.Patients were followed-up till the 4th week.Clinical symptoms such as skin rashes,jaundice,transaminase elevation,weak,pharyngalgia,as well as lab indices such as immunoglobulin and lymphocyte subclass were observed before and after treatment at week 4 and 12 of follow-ups.Results:(1)The total effective rate at week 2 was 96.1% in the treatment group,higher than that of control group(95.1%),but there was no statistical difference between them.(2)The time for fever,weak,jaundice and transaminase elevation was shorter in the treatment group than that in control group(P<0.05).(3)The positive cases of peripheral blood hetero-lymphocyte was significantly reduced after treatment at week 1 and 4 of follow-ups both in the two groups(P<0.01).The expressions of IgA,IgM and IgG decreased after treatment in the two groups when compared with those before treatment in the two groups(P<0.05,P<0.01).(4)After treatment,at week 1 and 4 of follow-ups,CD3^+ and CD8^+ decreased.CD4^+ and CD4/CD8 increased in the two groups hen compared with those before treatment(P<0.05).(5)B cells and NK cells increased more in the treatment group after treatment at week 1 and 4 of follow-ups,higher than that before treatment as well as those of the control group(P<0.05).Conclusion:Treatment of EB virus infection in youth by Chinese medicine was effective and it could promote the recovery of infection,and reduce the risk of vicious disease after infection.
作者 黄河银 张勤修 蒋路云 傅黎 何恒胜 吴小娟 兰建滨 HUANG Heyin;ZHANG Qinxiu;JIANG Luyun;FU Li;HE Hengsheng;WU Xiaojuan;LAN Jianbin(Chengdu University of TCM,Chengdu 610000,Siehuan,China;Department of E.N.T.,Sichuan traditional Chinese and Western Medieine Hospital,Chengdu 610000,Sichuan,China;Department of E.N.T.,Affiliated Hospital of Chengdu University of TCM,Chengdu 610000,Siehuan,China)
出处 《辽宁中医杂志》 CAS 2019年第1期13-16,共4页 Liaoning Journal of Traditional Chinese Medicine
基金 国家自然科学基金面上项目(81273985) 国家自然科学基金面上项目(81473523) 国家十二五科技支撑计划(2015BA I04B00).
关键词 EB病毒 中药 青年 免疫干预 EB virus Chinese medicine youth immune intervention
作者简介 黄河银(1986-),男,四川成都人,主治医师,博士研究生,研究方向:中西医结合防治耳鼻咽喉科疾病研究;通讯作者:张勤修(1968-),男,四川成都人,主任医师、教授,博士研究生导师,研究方向:中西医结合防治耳鼻咽喉科疾病研究,E—mail:zhqinxiu@163.com。
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