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地龙蛋白多肽类成分的研究进展 被引量:2

Research progress on proteins and peptides from earthworm
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摘要 动物药地龙药用历史悠久,资源丰富,为临床常用中药之一。现代研究表明蛋白多肽类为地龙主要成分,具有抗凝血、抗脑卒中、抗菌、抗纤维化等多方面的药理作用,已被应用于心脑血管等多种疾病的治疗。对1983年至今发现的48种地龙蛋白多肽类成分的名称、相对分子质量、氨基酸序列、等电点及其活性等进行总结,同时对地龙蛋白多肽类成分的药理作用研究进展进行较全面地综述,以期为地龙蛋白多肽类成分的深入研究与开发利用提供参考。 Earthworm is one of animal drugs in Chinese materia medica. It was commonly used in clinic with rich resources in China. Modern studies showed that proteins and peptides were the main components in earthworm. It has been used for treating cardiovascular and cerebrovascular diseases because of its various activities, such as anticoagulant, anti-stroke, antibacterial, and antifibrotic activities, etc. In this review, 48 proteins and peptides from different species of earthworm reported since 1983 were summarized, including their names, molecular weights, amino acid sequences, isoelectric points, and activities. In addition, its pharmacological effects of earthworm proteins and peptides were summarized. In all, it will provide a scientific basis for the further study and comprehensive utilization of proteins and peptides of earthworm.
作者 刘巧 毕启瑞 谭宁华 LIU Qiao;BI Qi-rui;TAN Ning-hua(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处 《中草药》 CAS CSCD 北大核心 2019年第1期252-261,共10页 Chinese Traditional and Herbal Drugs
基金 江苏省自然科学基金项目(BK20170738) 江苏省博士后科研资助项目(1701055A) 天然药物活性组分与药效国家重点实验室自主研究课题(3144060028)。
关键词 地龙 中药 蛋白 多肽 抗凝血 抗脑卒中 抗菌 抗纤维化 earthworm Chinese materia medica proteins peptides anticoagulant activity anti-stroke activity antibacterial activity antifibrotic activity
作者简介 刘巧(1994-),女,硕士研究生,研究方向为中药化学。Tel:15951712211 E-mail:1556423408@qq.com;通信作者:毕启瑞(1986-),男,博士,博士后,研究方向为中药分析。E-mail:biqirui@cpu.edu.cn;通信作者:谭宁华(1963-),女,博士生导师,教授,从事含环肽中药和止咳中药系统研究。E-mail:nhtan@cpu.edu.cn.
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