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乳腺肿瘤表观弥散系数与组织细胞密度相关性研究 预览 被引量:56

Comparison of Apparent Diffusion Coefficient (ADC) with Histologic Cellularity in Breast Tumors
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摘要 目的:评估组织细胞密度在良恶性乳腺病变弥散系数(Apparent Diffusion Coefficients,ADC)不同中所起的作用.材料和方法:对经手术病理证实的46例乳腺病变(恶性肿瘤26例,良性病变20例)进行磁共振弥散加权成像(Diffusion Weighted Imaging, DWI)检查,并计算病变的ADC值.用Adobe Photoshop 4.0 software 软件分析乳腺病变病理切片的细胞密度.统计分析ADC值与细胞密度的相关性.结果:恶性肿瘤平均ADC值为(0.9608±0.2043)×10-3mm2/s,明显小于良性病变组(1.5934±0.2084)×10-3mm2/s;P<0.001).恶性肿瘤平均细胞密度为(14.59±4.35)%,明显大于良性病变组(10.20±4.32%;P<0.05).乳腺病变ADC值与细胞密度的相关性很好(r=-0.542).结论:在乳腺良恶性肿瘤ADC不同中,细胞密度起了重要作用.通过测量肿瘤ADC鉴别乳腺良恶性病变是一个有效的方法,但仍有其局限性. Purpose: To compare ADC with tumor cellularity to explore the possible role of cell density in different ADC of breast lesions. Materials and Methods: Diffusion weighted MR images were acquired using a multi section spin echo type single shot EPI sequence in the sagittal plane. 46 patients with histologically proven benign (20) and malignant (26) breast lesions were studied. Mean ADC value of the breast lesions was calculated. Tumor cellularity, analyzed using Adobe Photoshop 4.0 software, was defined as the total area of nuclei of tumor cells divided by the area of the histology section studied.10 fields of views (original magnification×200) of each lesion were analyzed. Statistical comparison of the tumor cellularity with the mean ADC was made using simple linear regression analysis. Results:Mean ADC (in units of 10 -3 mm 2/sec) of malignant lesions (0.9608±0.2043) was statistically different from that of benign lesions (1.5934±0.2084, P<0.001). Mean cellularity of malignant lesions [(14.59±4.35)%] was statistically different from that of benign lesions [(10.20±4.32)%](P<0.05). The mean ADC value of the breast lesions correlated well with tumor cellularity (r= -0.542). Conclusion:Cellularity plays a big role on different ADCs of malignant and benign breast tumors. Measuring the ADCs of focal breast masses is an effective but limited method for characterizing the masses.
作者 郭勇 王辅林 蔡幼铨 蔡祖龙 高元桂 Guo Yong, Wang Fulin, Cai Youquan,Cai Zulong,Gao Yuangui(Department of Radiology, Navy General Hospital, Beijing, 100037)
机构地区 [ [ [
出处 《中国医学影像学杂志》 CSCD 2002年第4期 241-243,共3页 Chinese Journal of Medical Imaging
关键词 乳腺肿瘤 磁共振成像 回波平面成像 细胞密度 ADC 表观弥散系数 breast neoplasm magnetic resonance imaging echo-planar imaging cellularity
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参考文献7

  • 1Lucas-Quesada FA, Sinha S, Debruhl ND, et al. Estimation of coefficients for benign and malignant breast lesions using echo planar MR imaging. Radiology (Supplement),1998,209(p):468 被引量:1
  • 2郭勇,蔡祖龙,蔡幼铨,安宁豫,高元桂,马林,梁燕,弥散加权成像鉴别乳腺良恶性病变的价值初探[J].中华放射学杂志,2001,35(2):132-135. 被引量:58
  • 3Sugahara T, Korogi Y, Kochi M, et al. Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging,1999,9:53 被引量:1
  • 4Le Biha D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology,1986,161:401 被引量:1
  • 5Buadu LD, Murakami J, Murayama S, et alP. Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis. Radiology,1996,200:639 被引量:1
  • 6Noguchi K, Watanabe N, Nagayoshi T, et al. Role of diffusion-weighted echo-planar MRI in distinguishing between brain brain abscess and tumour: a preliminary report. Neuroradiology,1999,41(3):171 被引量:1
  • 7LeBihan D, Breton E, Lallemand D, et al. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology,1988,168:497 被引量:1

二级参考文献5

  • 1Kuhl C K,Radiology,1999年,211卷,101页 被引量:1
  • 2Daniel B L,Radiology,1998年,209卷,499页 被引量:1
  • 3Sinha S,Magnetic Resonance Imaging,1997年,7卷,1016页 被引量:1
  • 4Degani H,Nat Med,1997年,3卷,780页 被引量:1
  • 5Englander S A,NMR Biomed,1997年,10卷,348页 被引量:1

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